scholarly journals Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

2007 ◽  
Vol 282 (33) ◽  
pp. 23799-23810 ◽  
Author(s):  
Bruno Laugel ◽  
Hugo A. van den Berg ◽  
Emma Gostick ◽  
David K. Cole ◽  
Linda Wooldridge ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activation ◽  
Cell Receptor ◽  
Binding Properties ◽  
Receptor Affinity ◽  
Tetramer Binding ◽  
T Lymphocyte Activation

scholarly journals The β1and β3Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation

2003 ◽  
Vol 278 (29) ◽  
pp. 26983-26991 ◽  
Author(s):  
Marie-Agnès Doucey ◽  
Daniel F. Legler ◽  
Mustapha Faroudi ◽  
Nicole Boucheron ◽  
Petra Baumgaertner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Activation ◽  
Cell Receptor ◽  
T Lymphocyte Activation

Immunodeficiency with low expression of the T cell receptor/CD3 complex. Effect on T lymphocyte activation

1991 ◽  
Vol 21 (7) ◽  
pp. 1641-1647 ◽  
Author(s):  
Françoise Le Deist ◽  
Gabriela Thoenes ◽  
José Corado ◽  
Barbara Lisowska-Grospierre ◽  
Alain Fischer
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
Cell Receptor ◽  
Complex Effect ◽  
T Lymphocyte Activation ◽  
Low Expression

Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor

1996 ◽  
Vol 26 (11) ◽  
pp. 2781-2789 ◽  
Author(s):  
Valter Redoglia ◽  
Umberto Dianzani ◽  
Josè M. Rojo ◽  
Pilàr Portolés ◽  
Manuela Bragardo ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
Cell Receptor ◽  
T Lymphocyte Activation

scholarly journals Ligation of Cytotoxic T Lymphocyte Antigen-4 to T Cell Receptor Inhibits T Cell Activation and Directs Differentiation into Foxp3+Regulatory T Cells

2012 ◽  
Vol 287 (14) ◽  
pp. 11098-11107 ◽  
Author(s):  
Jozsef Karman ◽  
Ji-Lei Jiang ◽  
Nathan Gumlaw ◽  
Hongmei Zhao ◽  
Juanita Campos-Rivera ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
T Lymphocyte ◽  
Cell Activation ◽  
Cytotoxic T Lymphocyte ◽  
Cell Receptor ◽  
Lymphocyte Antigen

scholarly journals Differential T cell receptor photoaffinity labeling among H-2Kd restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative. Labeling of the alpha-chain correlates with J alpha segment usage.

1993 ◽  
Vol 177 (5) ◽  
pp. 1247-1256 ◽  
Author(s):  
P Romero ◽  
J L Casanova ◽  
J C Cerottini ◽  
J L Maryanski ◽  
I F Luescher
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Photoaffinity Labeling ◽  
Cell Receptor ◽  
Tryptophan Residue ◽  
Alpha Chain ◽  
Peptide Derivative ◽  
Specificity Pattern

Using a direct binding assay based on photoaffinity labeling, we studied the interaction of T cell receptor (TCR) with a Kd-bound photoreactive peptide derivative on living cells. The Kd-restricted Plasmodium berghei circumsporozoite (PbCS) peptide 253-260 (YIPSAEKI) was reacted NH2-terminally with biotin and at the TCR contact residue Lys259 with photoreactive iodo, 4-azido salicylic acid (IASA) to make biotin-YIPSAEK(IASA)I. Cytotoxic T lymphocyte (CTL) clones derived from mice immunized with this derivative recognized this conjugate, but not a related one lacking the IASA group nor the parental PbCS peptide. The clones were Kd restricted. Recognition experiments with variant conjugates, lacking substituents from IASA, revealed a diverse fine specificity pattern and indicated that this group interacted directly with the TCR. The TCR of four clones could be photoaffinity labeled by biotin-YIPSAEK(125IASA)I. This labeling was dependent on the conjugates binding to the Kd molecule and was selective for the TCR alpha (2 clones) or beta chain (1 clone), or was common for both chains (1 clone). TCR sequence analysis showed a preferential usage of J alpha TA28 containing alpha chains that were paired with V beta 1 expressing beta chains. The TCR that were photoaffinity labeled at the alpha chain expressed these J alpha and V beta segments. The tryptophan encoded by the J alpha TA28 segment is rarely found in other J alpha segments. Moreover, we show that the IASA group interacts preferentially with tryptophan in aqueous solution. We thus propose that for these CTL clones, labeling of the alpha chain occurs via the J alpha-encoded tryptophan residue.

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