scholarly journals Control of Death-associated Protein Kinase (DAPK) Activity by Phosphorylation and Proteasomal Degradation

2006 ◽  
Vol 281 (51) ◽  
pp. 39033-39040 ◽  
Author(s):  
Yijun Jin ◽  
Emily K. Blue ◽  
Patricia J. Gallagher
Keyword(s):  
Protein Kinase ◽  
Proteasomal Degradation ◽  
Death Associated Protein Kinase

Silencing of a death associated protein kinase as a pro-survival factor in colon cancer cells

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
GA Doherty ◽  
SM Byrne ◽  
SC Austin ◽  
GM Scully ◽  
EW Kay ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Survival Factor ◽  
Death Associated Protein Kinase

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins

2015 ◽  
Vol 464 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Keizo Yuasa ◽  
Reina Ota ◽  
Shinya Matsuda ◽  
Kinuka Isshiki ◽  
Masahiro Inoue ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Death Associated Protein Kinase

scholarly journals Regulation of the Death-Associated Protein Kinase 1 Expression and Autophagy via ATF6 Requires Apoptosis Signal-Regulating Kinase 1

2014 ◽  
Vol 34 (21) ◽  
pp. 4033-4048 ◽  
Author(s):  
P. Gade ◽  
S. B. Manjegowda ◽  
S. C. Nallar ◽  
U. B. Maachani ◽  
A. S. Cross ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Death Associated Protein Kinase

scholarly journals Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma

2010 ◽  
Vol 28 (2) ◽  
Author(s):  
Ismário Silva de Meneses ◽  
Rafael Reis de Souza ◽  
Verónica de Lourdes Sierpe Jeraldo ◽  
Danielle Rodrigues Ribeiro Cavalcante ◽  
Francisco Prado Reis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Grade ◽  
Death Associated Protein Kinase

scholarly journals Meta-analysis: Assocation between promoter hypermethylation of DAPK (Death-Associated Protein Kinase) and cervical cancer

2020 ◽  
Vol 9 (1) ◽  
pp. 41-50
Author(s):  
Lao Duc Thuan ◽  
Truong Kim Phuong
Keyword(s):  
Cervical Cancer ◽  
Protein Kinase ◽  
Promoter Methylation ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Promoter Hypermethylation ◽  
Aberrant Methylation ◽  
Case Control Studies ◽  
Death Associated Protein Kinase

Purpose: Death-associated protein kinase (DAPK or DAPK1) is an important tumor suppressor protein that involved in the regulation of cell activities. The aberrant methylation of DAPK promoter has been reported in patients with cervical cancer. However, the association between of DAPK1 and cervical cancer was not always unification, in previous studies. Therefore, in current study, a meta-analysis was performed for association of between DAPK gene’s promoter hypermethylated and cervical cancer. Methods: A systematic literature analysis was conducted based on the previous studies published in PubMed, PubMed Central (NCBI), Google by using following keywords: cervical cancer, cervical carcinoma, Methylation, by the end of January, 2018. The association between DAPK promoter methylation and cervical cancer was evaluated by odds ratio (ORs) and 95% confidence intervals (CI). To evaluate the potential sources of heterogeneity, the meta-regression analysis and subgroup analysis were conducted. Results: A total of 21 case-control studies which relevant to the association between DAPK1 gene’s promoter methylation frequency and cervical cancer, that including 1600 cancer cases and 1011 control cases (non-cancerous cases). The analysis results indicated that the characteristic of candidate gene’s promoter methylation increased the cervical cancer risk through the calculation of OR value (OR = 21.25; 95% CI = 8.73 – 52.97; p < 0.001; Random effect model). The association between DAPK1 gene’s promoter hypermethylation was confirmed in all the subgroups analyses, including materials and assays methods, ethnicity. Furthermore, this association is higher in cervical squamous cell carcinoma than cervical adenocarcinoma and is a characteristic of late-stage disease. Conclusion: The hypermethylated DAPK1 gene’s promoter was also one of etiological factor, lead to the cervical tumorigenesis.

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