scholarly journals Modulation of Kv3.1b Potassium Channel Phosphorylation in Auditory Neurons by Conventional and Novel Protein Kinase C Isozymes

2006 ◽  
Vol 281 (22) ◽  
pp. 15582-15591 ◽  
Author(s):  
Ping Song ◽  
Leonard K. Kaczmarek
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Potassium Channel ◽  
Auditory Neurons ◽  
Kinase C ◽  
Novel Protein

scholarly journals Physiological Role for Phosphatidic Acid in the Translocation of the Novel Protein Kinase C Apl II in Aplysia Neurons

2008 ◽  
Vol 28 (15) ◽  
pp. 4719-4733 ◽  
Author(s):  
Carole A. Farah ◽  
Ikue Nagakura ◽  
Daniel Weatherill ◽  
Xiaotang Fan ◽  
Wayne S. Sossin
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phosphatidic Acid ◽  
Physiological Role ◽  
C2 Domain ◽  
The Novel ◽  
Physiological Conditions ◽  
Kinase C ◽  
Neuronal Membranes ◽  
Novel Protein

ABSTRACT In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. The orthologue of PKC Apl II, PKCε, has been reported to require phosphatidic acid (PA) in conjunction with diacylglycerol (DAG) for translocation. We find that PKC Apl II can be synergistically translocated to membranes by the combination of DAG and PA. We identify a mutation in the C1b domain (arginine 273 to histidine; PKC Apl II-R273H) that removes the effects of exogenous PA. In Aplysia neurons, the inhibition of endogenous PA production by 1-butanol inhibited the physiological translocation of PKC Apl II by serotonin in the cell body and at the synapse but not the translocation of PKC Apl II-R273H. The translocation of PKC Apl II-R273H in the absence of PA was explained by two additional effects of this mutation: (i) the mutation removed C2 domain-mediated inhibition, and (ii) the mutation decreased the concentration of DAG required for PKC Apl II translocation. We present a model in which, under physiological conditions, PA is important to activate the novel PKC Apl II both by synergizing with DAG and removing C2 domain-mediated inhibition.

scholarly journals Protein kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis

Heart Rhythm ◽  
2011 ◽  
Vol 8 (10) ◽  
pp. 1641-1647 ◽  
Author(s):  
Vikram A. Kanda ◽  
Kerry Purtell ◽  
Geoffrey W. Abbott
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Potassium Channel ◽  
Kinase C

scholarly journals Novel Protein Kinase C δ Isoform Insensitive to Caspase-3

2001 ◽  
Vol 24 (9) ◽  
pp. 973-977 ◽  
Author(s):  
Yoshiaki SAKURAI ◽  
Yoshiaki ONISHI ◽  
Yutaka TANIMOTO ◽  
Harutoshi KIZAKI
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Caspase 3 ◽  
Kinase C ◽  
Novel Protein

scholarly journals TRESK (K2P18.1) Background Potassium Channel Is Activated by Novel-Type Protein Kinase C via Dephosphorylation

2019 ◽  
Vol 95 (6) ◽  
pp. 661-672 ◽  
Author(s):  
Enikő Pergel ◽  
Miklós Lengyel ◽  
Péter Enyedi ◽  
Gábor Czirják
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Potassium Channel ◽  
Kinase C ◽  
Type Protein

Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer

Phytomedicine ◽  
2019 ◽  
Vol 65 ◽  
pp. 153100 ◽  
Author(s):  
Yuwei Wang ◽  
Chunping Tang ◽  
Sheng Yao ◽  
Huanling Lai ◽  
Runze Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Kinase C ◽  
Croton Tiglium ◽  
Novel Protein
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