scholarly journals Glucocorticoid-induced Tumor Necrosis Factor Receptor Is a p21Cip1/WAF1Transcriptional Target Conferring Resistance of Keratinocytes to UV Light-induced Apoptosis

2005 ◽  
Vol 280 (45) ◽  
pp. 37725-37731 ◽  
Author(s):  
Jian Wang ◽  
Vikram Devgan ◽  
Marcella Corrado ◽  
Nita S. Prabhu ◽  
Wafik S. El-Deiry ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Uv Light ◽  
Tumor Necrosis Factor Receptor ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals Apparently Normal Tumor Necrosis Factor Receptor 1 Signaling in the Absence of the Silencer of Death Domains

2003 ◽  
Vol 23 (18) ◽  
pp. 6609-6617 ◽  
Author(s):  
Robert Endres ◽  
Georg Häcker ◽  
Inge Brosch ◽  
Klaus Pfeffer
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Death Receptor ◽  
High Dose ◽  
Wild Type ◽  
Induced Apoptosis ◽  
Necrosis Factor

ABSTRACT The silencer of death domains (SODD) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 (TNFR1) in the absence of ligand. Besides TNFR1, death receptor 3 (DR3), Hsp70/Hsc70, and Bcl-2 have been characterized as binding partners of SODD. In order to investigate the in vivo role of SODD, we generated mice congenitally deficient in expression of the sodd gene. No spontaneous inflammatory infiltrations were observed in any organ of these mice. Consistent with this finding, in the absence of SODD no alteration in the activation patterns of nuclear factor κB (NF-κB), stress kinases, or ERK1 or -2 was observed after stimulation with tumor necrosis factor (TNF). Activation of NF-κB by DR3 was also unchanged. The extents of DR3- and TNF-induced apoptosis were comparable in gene-deficient and wild-type cells. Protection of cells against heat shock as mediated by the Hsp70 system and against staurosporine-induced apoptosis was independent of SODD. Furthermore, resistance to high-dose lipopolysaccharide (LPS) injections, LPS-d-GalN injections, and infection with listeriae was similar in wild-type and gene-deficient mice. In conclusion, our data do not support the concept of a unique, nonredundant role of SODD for the functions of TNFR1, Hsp70, and DR3.

scholarly journals I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 ◽  
Vol 272 (28) ◽  
pp. 17255-17257 ◽  
Author(s):  
Shimin Hu ◽  
Claudius Vincenz ◽  
Jian Ni ◽  
Reiner Gentz ◽  
Vishva M. Dixit
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals Antisense Oligonucleotide Inhibition of Tumor Necrosis Factor Receptor 1 Protects the Liver from Radiation-Induced Apoptosis

2006 ◽  
Vol 12 (9) ◽  
pp. 2849-2855 ◽  
Author(s):  
Xiao W. Huang ◽  
Jiong Yang ◽  
Aleksandar F. Dragovic ◽  
Hong Zhang ◽  
Theodore S. Lawrence ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals Phosphorylation of Tumor Necrosis Factor Receptor 1 (p55) Protects Macrophages from Silica-induced Apoptosis

2003 ◽  
Vol 279 (3) ◽  
pp. 2020-2029 ◽  
Author(s):  
Federica Gambelli ◽  
Peter Di ◽  
Xiaomei Niu ◽  
Mitchell Friedman ◽  
Timothy Hammond ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis

2000 ◽  
Vol 276 (11) ◽  
pp. 8087-8093 ◽  
Author(s):  
Eugen Leo ◽  
Quinn L. Deveraux ◽  
Christian Buchholtz ◽  
Kate Welsh ◽  
Shu-ichi Matsuzawa ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Induced Apoptosis ◽  
Necrosis Factor

scholarly journals FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 ◽  
Vol 271 (9) ◽  
pp. 4961-4965 ◽  
Author(s):  
Arul M. Chinnaiyan ◽  
Clifford G. Tepper ◽  
Michael F. Seldin ◽  
Karen O'Rourke ◽  
Frank C. Kischkel ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Induced Apoptosis ◽  
Necrosis Factor
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