scholarly journals Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death

2005 ◽  
Vol 280 (31) ◽  
pp. 28775-28784 ◽  
Author(s):  
Jeong Chan Moon ◽  
Young-Sool Hah ◽  
Woe Yeon Kim ◽  
Bae Gyo Jung ◽  
Ho Hee Jang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Hela Cell ◽  
Cell Resistance ◽  
Functional Switching ◽  
Stress Dependent

scholarly journals New Triazolothiadiazine Derivative Inhibits Stemness and Induces Cell Death in HCC by Oxidative Stress Dependent JNK Pathway Activation

2021 ◽  
Author(s):  
Deniz Cansen Kahraman ◽  
Ebru Bilget Guven ◽  
Peri S. Aytac ◽  
Gamze Aykut ◽  
Birsen Tozkoparan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Disease Free Survival ◽  
Phase Cell ◽  
Jnk Pathway ◽  
Ability To Act ◽  
Incidence And Mortality ◽  
Anti Inflammatory ◽  
Stress Dependent ◽  
Hcc Cells

Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. (NSAIDs) Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence and mortality of different types of cancers. Here, we investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on HCC, which have been previously reported as potent analgesic/anti-inflammatory compounds. From the initially tested 32 triazolothiadiazine NSAID derivatives, 3 compounds were selected based on their IC50 values for further molecular assays on 9 different HCC cell lines. 7b, which was the most potent compound, induced G2/M phase cell cycle arrest and apoptosis in HCC cells. Cell death was due to oxidative stress-induced JNK protein activation, which involved the dynamic involvement of ASK1, MKK7, and c-Jun proteins. Moreover, 7b treated nude mice had a significantly decreased tumor volume and prolonged disease-free survival. 7b also inhibited the migration of HCC cells and enrichment of liver cancer stem cells (LCSCs) alone or in combination with sorafenib. With its ability to act on both proliferation, stemness and the migration of HCC cells, 7b can be considered for the therapeutics of HCC, which has an increased rate of incidence ~3% annually.

scholarly journals Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat

2015 ◽  
Vol 7 ◽  
Author(s):  
Selva Rivas-Arancibia ◽  
Luis Fernando Hernández Zimbrón ◽  
Erika Rodríguez-Martínez ◽  
Perla D. Maldonado ◽  
Gabino Borgonio Pérez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Substantia Nigra ◽  
Immune Responses ◽  
Ozone Exposure ◽  
Stress Dependent

Andrographolide induces oxidative stress-dependent cell death in unicellular protozoan parasite Trypanosoma brucei

Acta Tropica ◽  
2017 ◽  
Vol 176 ◽  
pp. 58-67 ◽  
Author(s):  
Malabika Banerjee ◽  
Debaprasad Parai ◽  
Pranab Dhar ◽  
Manab Roy ◽  
Rajib Barik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Trypanosoma Brucei ◽  
Protozoan Parasite ◽  
Dependent Cell ◽  
Stress Dependent
Sign in / Sign up

Export Citation Format

Share Document