scholarly journals Role of the Lid Hydrophobicity Pattern in Pancreatic Lipase Activity

2005 ◽  
Vol 280 (48) ◽  
pp. 40074-40083 ◽  
Author(s):  
Annick Thomas ◽  
Maya Allouche ◽  
Frédéric Basyn ◽  
Robert Brasseur ◽  
Brigitte Kerfelec
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity

scholarly journals Modification of a phospholipid stabilized emulsion interface by bile salt: effect on pancreatic lipase activity

1998 ◽  
Vol 39 (3) ◽  
pp. 623-632 ◽  
Author(s):  
Martin Wickham ◽  
Martin Garrood ◽  
John Leney ◽  
Peter D.G. Wilson ◽  
Annette Fillery-Travis
Keyword(s):  
Bile Salt ◽  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Salt Effect

scholarly journals Studies on the detergent inhibition of pancreatic lipase activity.

1983 ◽  
Vol 24 (10) ◽  
pp. 1336-1342
Author(s):  
Y Gargouri ◽  
R Julien ◽  
A G Bois ◽  
R Verger ◽  
L Sarda
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity

scholarly journals Kinetic studies on pancreatic lipase activity in micellar systems. II. Effect of fatty acid chain length of substrates.

1983 ◽  
Vol 31 (12) ◽  
pp. 4213-4219 ◽  
Author(s):  
HIROSHI NAKAHARA ◽  
SATOSHI OKADA ◽  
KENSHU MOCHIDA ◽  
HIDENOBU OHMORI ◽  
MASAICHIRO MASU
Keyword(s):  
Fatty Acid ◽  
Chain Length ◽  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Kinetic Studies ◽  
Fatty Acid Chain Length ◽  
Fatty Acid Chain ◽  
Micellar Systems

scholarly journals Physiological parameters governing the action of pancreatic lipase

2010 ◽  
Vol 23 (1) ◽  
pp. 146-154 ◽  
Author(s):  
Iain A. Brownlee ◽  
Deborah J. Forster ◽  
Matthew D. Wilcox ◽  
Peter W. Dettmar ◽  
Chris J. Seal ◽  
...  
Keyword(s):  
Weight Management ◽  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Dietary Lipid ◽  
Ion Concentration ◽  
Lipid Absorption ◽  
Energy Yield ◽  
Body Of Knowledge ◽  
Lipid Ester ◽  
Duodenal Lumen

The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the action of pancreatic lipase under the range of physiological conditions that occur within the human small intestine, and the literature that does exist is often contradictory. Due to the importance of pancreatic lipase activity to nutrition and weight management, the present review aims to assess the current body of knowledge with regards to the physiology behind the action of this unique gastrointestinal enzyme system. Existing data would suggest that pancreatic lipase activity is affected by intestinal pH, the presence of colipase and bile salts, but not by the physiological range of Ca ion concentration (as is commonly assumed). The control of secretion of pancreatic lipase and its associated factors appears to be driven by gastrointestinal luminal content, particularly the presence of acid or digested proteins and fats in the duodenal lumen. Secretion of colipase, bile acids and pancreatic lipase is driven by cholecystokinin and secretin release.

scholarly journals Prognostic value of canine pancreatic lipase immunoreactivity and lipase activity in dogs with gastric dilatation-volvulus

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0204216 ◽  
Author(s):  
Giuseppe Spinella ◽  
Francesco Dondi ◽  
Lisa Grassato ◽  
Luca Magna ◽  
Veronica Cola ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Prognostic Value ◽  
Gastric Dilatation

Evaluation of lipase activity in serum by radial enzyme diffusion.

1976 ◽  
Vol 22 (5) ◽  
pp. 633-637 ◽  
Author(s):  
J M Goldberg ◽  
P Pagast
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Reference Method ◽  
Pancreatic Disease ◽  
Serum Lipase ◽  
Normal Limits ◽  
Diffusion Assay

Abstract Results of determination of serum lipase by radial enzyme diffusion correlate well with those by a titrimetric reference method in the abnormal range. The specificity of the diffusion assay allows the differentiation of patients with pancreatic disease, even when the lipase activity of the serum is within the normal limits of the tritrimetric assay. Pancreatic lipase is not detectable by the diffusion assay in the serum of individuals who are free from pancreatic disease.

scholarly journals Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101
Author(s):  
Souichi Nakashima ◽  
Tomoe Ohta ◽  
Seikou Nakamura ◽  
Yoshimi Oda ◽  
Mari Koumoto ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Methanol Extract ◽  
Bacopa Monniera ◽  
Inhibitory Effects ◽  
Active Constituent ◽  
Structural Requirements ◽  
Phenylpropanoid Glycosides ◽  
First Time

The methanol extract of whole Bacopa monniera plants inhibited pancreatic lipase activity in vitro. From this extract we have reported the isolation of 11 triterpene glycosides and 5 phenylethanoid- and/or phenylpropanoid- glycosides. In this paper, we describe the effects of the methanol extract and/or its constituents on pancreatic lipase activity and the isolation of an active constituent, desrhamnosyl isoacteoside. In addition, the structural requirements for its inhibitory effects were examined. We also examined the effects on the elevation of plasma triglyceride (TG) levels in olive oil loaded mice. The major active constituents, desrhamnosyl isoacteoside and plantainoside B, reduced plasma TG levels in the mice. The inhibitory effects of B. monniera and its constituents on pancreatic lipase activity and plasma TG level are reported for the first time.

Gallotannins are uncompetitive inhibitors of pancreatic lipase activity

2020 ◽  
Vol 264 ◽  
pp. 106409
Author(s):  
Elena N. Moreno-Córdova ◽  
Aldo A. Arvizu-Flores ◽  
Elisa M. Valenzuela-Soto ◽  
Karina D. García-Orozco ◽  
Abraham Wall-Medrano ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity
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