scholarly journals Superoxide Anion Radical Modulates the Activity of Ras and Ras-related GTPases by a Radical-based Mechanism Similar to That of Nitric Oxide

2005 ◽  
Vol 280 (13) ◽  
pp. 12438-12445 ◽  
Author(s):  
Jongyun Heo ◽  
Sharon L. Campbell
Keyword(s):  
Nitric Oxide ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Superoxide Anion Radical

scholarly journals INTENSITY OF NITRIC OXIDE SYNTHESIS IN THE BLOOD OF RATS UNDER THE INFLUENCE OF SODIUM FLUORIDE

2020 ◽  
Vol 24 (5-6) ◽  
pp. 25-28
Author(s):  
I.L. Kolisnyk
Keyword(s):  
Nitric Oxide ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Structural Changes ◽  
Biological Effects ◽  
The Body ◽  
Superoxide Anion Radical ◽  
Chemical Agent ◽  
High Concentrations ◽  
Nitrate Anions

The influence of fluoride ion as a chemical agent affects the metabolism, the change of which is manifested in functional and structural changes. The final stable metabolites of NO include nitrite and nitrate anions (NO2, NO3), the concentration of which serves as an indirect method for estimating the intensity of NO synthesis. The concentration of NO is a major factor in its numerical biological effects (regulatory, protective). At low NO concentrations, direct effects aimed at maintaining homeostasis, such as the vascular, respiratory, and nervous systems, predominate; at high concentrations of NO, indirect effects prevail, due primarily to the formation of peroxynitrite. It is known that when the rate of free radical reactions in the body increases, NO can react with a superoxide anion radical to form peroxynitrite, a highly reactive compound with destructive properties against proteins and lipids. Oral administration of FN to rats in doses of 1/10 and 1/100 DL50 leads to an increase in the content of nitrite and nitrate anions in the blood plasma during the first 30 days, which indirectly indicates excess production of nitric oxide, which in the initial stages of intoxication may play a compensatory role, but subsequently cause pathological reactions associated with the activation of oxidative stress. The decrease in nitrite and nitrate anions at the end of long-term action of FN indirectly indicates a decrease in nitric oxide generation, which may be associated, in particular, with an increase in peroxynitrite concentration due to the use of nitric oxide in reaction with superoxide anion radical and antioxidant deficiency.

scholarly journals Coordination Between Nitric Oxide and Superoxide Anion Radical During Progressive Exercise in Elite Soccer Players

2010 ◽  
Vol 4 ◽  
pp. 100-106 ◽  
Author(s):  
Dusica Djordjevic ◽  
Vladimir Jakovljevic ◽  
Dejan Cubrilo ◽  
Miroljub Zlatkovic ◽  
Vladimir Zivkovic ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Superoxide Anion Radical ◽  
Soccer Players ◽  
Progressive Exercise

Superoxide Anion Radical: Generation and Detection in Cellular and Non-Cellular Systems

2015 ◽  
Vol 22 (37) ◽  
pp. 4234-4256 ◽  
Author(s):  
Renan Chiste ◽  
Marisa Freitas ◽  
Adriana Mercadante ◽  
Eduarda Fernandes
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Cellular Systems ◽  
Superoxide Anion Radical ◽  
Radical Generation

scholarly journals Effect of extraction conditions of paprika oleoresins on their free radical scavenging and anticancer activity

2014 ◽  
Vol 12 (3) ◽  
pp. 377-385 ◽  
Author(s):  
Vesna Šaponjac ◽  
Dragana Četojević-Simin ◽  
Gordana Ćetković ◽  
Jasna Čanadanović-Brunet ◽  
Sonja Djilas ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Cell Line ◽  
Antiproliferative Activity ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Radical Scavenging ◽  
Superoxide Anion Radical ◽  
Food Ingredients ◽  
Supercritical Carbon

AbstractGround spice paprika was extracted with hexane, by conventional Soxhlet procedure (SX oleoresin), and with supercritical carbon dioxide at three different pressures — 20, 30 and 40 MPa (SF20, SF30 and SF40 oleoresins). The effect of extraction method and conditions on the colour intesity of paprika oleoresins, content of α-tocopherol, as well as antioxidant and antiproliferative activity was examined. Hexane showed highest selectivity for paprika pigments (886.02 ASTA), while α-tocopherol showed highest solubility (3846.9 mg kg−1) in supercritical carbon dioxide at 20 MPa. All paprika oleoresins exhibited good superoxide anion radical scavenging activity SF30 being the best superoxide anion radical scavenger. Cell growth activity was evaluated in vitro in human cell lines:cervix epitheloid carcinoma (HeLa), breast adenocarcinoma (MCF7) and colon adenocarcinoma (HT-29). The highest antiproliferative activity was exhibited by SX in MCF7 cell line (IC50=14.28 mg mL−1). Extract SF40 produced significant and selective antiproliferative action towards HeLa cell line. These results suggest that paprika oleoresins, due to high antiradical and tumor cell-inhibiting activity, can be regarded as functional food ingredients.

Sign in / Sign up

Export Citation Format

Share Document