scholarly journals c-Abl Tyrosine Kinase Regulates Caspase-9 Autocleavage in the Apoptotic Response to DNA Damage

2005 ◽  
Vol 280 (12) ◽  
pp. 11147-11151 ◽  
Author(s):  
Deepak Raina ◽  
Pramod Pandey ◽  
Rehan Ahmad ◽  
Ajit Bharti ◽  
Jian Ren ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tyrosine Kinase ◽  
Caspase 9 ◽  
Apoptotic Response ◽  
Abl Tyrosine Kinase

The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage

APOPTOSIS ◽  
2010 ◽  
Vol 15 (8) ◽  
pp. 927-935 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Yoshio Miki ◽  
Kiyotsugu Yoshida
Keyword(s):  
Dna Damage ◽  
Tyrosine Kinase ◽  
Apoptotic Response ◽  
Abl Tyrosine Kinase

scholarly journals c-Abl Tyrosine Kinase Regulates the Human Rad9 Checkpoint Protein in Response to DNA Damage

2002 ◽  
Vol 22 (10) ◽  
pp. 3292-3300 ◽  
Author(s):  
Kiyotsugu Yoshida ◽  
Kiyoshi Komatsu ◽  
Hong-Gang Wang ◽  
Donald Kufe
Keyword(s):  
Dna Damage ◽  
Tyrosine Kinase ◽  
Genotoxic Stress ◽  
Cell Cycle Checkpoint ◽  
Apoptotic Response ◽  
Checkpoint Protein ◽  
Abl Tyrosine Kinase ◽  
Cycle Checkpoint ◽  
Induced Apoptosis

ABSTRACT The ubiquitously expressed c-Abl tyrosine kinase is activated in the apoptotic response of cells to DNA damage. The mechanisms by which c-Abl signals the induction of apoptosis are not understood. Here we show that c-Abl binds constitutively to the mammalian homolog of the Schizosaccharomyces pombe Rad9 cell cycle checkpoint protein. The SH3 domain of c-Abl interacts directly with the C-terminal region of Rad9. c-Abl phosphorylates the Rad9 Bcl-2 homology 3 domain (Tyr-28) in vitro and in cells exposed to DNA-damaging agents. The results also demonstrate that c-Abl-mediated phosphorylation of Rad9 induces binding of Rad9 to the antiapototic Bcl-xL protein. The regulation of Rad9 by c-Abl in the DNA damage response is further supported by the demonstration that the interaction between c-Abl and Rad9 contributes to DNA damage-induced apoptosis. These findings indicate that Rad9 is regulated by a c-Abl-dependent mechanism in the apoptotic response to genotoxic stress.

Involvement of c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents

1999 ◽  
pp. 87-98
Author(s):  
Zhi-Min Yuan ◽  
Surender Kharbanda ◽  
Ralph Weichselbaum ◽  
Donald Kufe
Keyword(s):  
Tyrosine Kinase ◽  
Anticancer Agents ◽  
Apoptotic Response ◽  
Abl Tyrosine Kinase

Proliferating cell nuclear antigen destabilizes c-Abl tyrosine kinase and regulates cell apoptosis in response to DNA damage

APOPTOSIS ◽  
2009 ◽  
Vol 14 (3) ◽  
pp. 268-275 ◽  
Author(s):  
Xiang He ◽  
Congwen Wei ◽  
Ting Song ◽  
Jing Yuan ◽  
Yanhong Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tyrosine Kinase ◽  
Cell Apoptosis ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Abl Tyrosine Kinase ◽  
Proliferating Cell

c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage

2014 ◽  
Vol 26 (2) ◽  
pp. 444-452 ◽  
Author(s):  
S.M. Nashir Udden ◽  
Yuiko Morita-Fujimura ◽  
Masanobu Satake ◽  
Shuntaro Ikawa
Keyword(s):  
Dna Damage ◽  
Tyrosine Kinase ◽  
Cell Fate ◽  
Cell Fate Decision ◽  
Abl Tyrosine Kinase ◽  
Fate Decision
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