scholarly journals An Atypical Tumor Necrosis Factor (TNF) Receptor-associated Factor-binding Motif of B Cell-activating Factor Belonging to the TNF Family (BAFF) Receptor Mediates Induction of the Noncanonical NF-κB Signaling Pathway

2005 ◽  
Vol 280 (11) ◽  
pp. 10018-10024 ◽  
Author(s):  
Matthew D. Morrison ◽  
William Reiley ◽  
Minying Zhang ◽  
Shao-Cong Sun
Keyword(s):  
Tumor Necrosis Factor ◽  
B Cell ◽  
Signaling Pathway ◽  
Tumor Necrosis ◽  
Binding Motif ◽  
Tnf Receptor ◽  
Associated Factor ◽  
Factor Binding ◽  
B Cell Activating Factor ◽  
Necrosis Factor

scholarly journals Expression of TNF-α, April and BCMA in Behcet’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Olfat G. Shaker ◽  
Shereen O. Tawfic ◽  
Amira M. El-Tawdy ◽  
Mohamed H. M. El-Komy ◽  
Manal El Menyawi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
B Cell ◽  
Behçet’S Disease ◽  
Tumor Necrosis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Serum Levels ◽  
Behcet's Disease ◽  
B Cell Activating Factor ◽  
Necrosis Factor

Background. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine which plays an important role in the immunopathogenesis of Behcet’s disease (BD). B cell activating factor (BAFF) and its homolog A proliferation inducing ligand (APRIL) are members of the tumor necrosis factor family. BAFF binds to 3 receptors, B cell activating factor receptor (BAFF-R), transmembrane activator and calcium modulator ligand interactor (TACI), and B cell maturation antigen (BCMA) that are expressed by B cells.Objective. Estimation of the serum levels of TNF-α, APRIL, BAFF, and BCMA in patients with BD in an effort to evaluate their degree of involvement in the pathogenesis and development of BD.Patients and Methods. This study included 30 male patients fulfilling the international study group criteria for the diagnosis of BD. Twenty age-matched healthy male volunteers served as control. Serum samples were used for quantification of TNF-α, APRIL, BCMA, BAFF, and hsCRP using ELISA techniques.Results. The mean serum levels of TNF-α, APRIL, BCMA, and BAFF were more elevated in cases than in controls in a statistically significant manner(P<0.001). Positive correlation was observed between hs-CRP and BDCAF (Behcet’s disease current activity forum) index (r0.68,P<0.001). None of the TNF family members tested was affected by a positive pathergy test.Conclusions. Patients have significantly higher levels of TNF family members’ (TNF-α, BAFF, APRIL, and BCMA) compared to controls which might contribute to the pathogenesis of BD.

scholarly journals Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)†

Biochemistry ◽  
2006 ◽  
Vol 45 (7) ◽  
pp. 2006-2013 ◽  
Author(s):  
Teresa G. Cachero ◽  
Ian M. Schwartz ◽  
Fang Qian ◽  
Eric S. Day ◽  
Claudia Bossen ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
B Cell ◽  
Family Member ◽  
Tumor Necrosis ◽  
Intrinsic Property ◽  
Tumor Necrosis Factor Family ◽  
B Cell Activating Factor ◽  
Necrosis Factor
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