scholarly journals Heat Shock Protein 27 Is the Major Differentially Phosphorylated Protein Involved in Renal Epithelial Cellular Stress Response and Controls Focal Adhesion Organization and Apoptosis

2005 ◽  
Vol 280 (33) ◽  
pp. 29885-29898 ◽  
Author(s):  
Marjo de Graauw ◽  
Ine Tijdens ◽  
Rainer Cramer ◽  
Steve Corless ◽  
John F. Timms ◽  
...  
Keyword(s):  
Stress Response ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Focal Adhesion ◽  
Cellular Stress ◽  
Heat Shock Protein 27 ◽  
Cellular Stress Response ◽  
Phosphorylated Protein

scholarly journals The cellular stress response of rat skeletal muscle following lengthening contractions

2017 ◽  
Vol 42 (7) ◽  
pp. 708-715 ◽  
Author(s):  
Evan Pollock-Tahiri ◽  
Marius Locke
Keyword(s):  
Stress Response ◽  
Heat Shock ◽  
Muscle Fibre ◽  
Cellular Stress ◽  
Cellular Stress Response ◽  
In Vivo Model ◽  
Morphological Evidence ◽  
Lengthening Contractions ◽  
Single Set

The cellular stress response of the rat tibialis anterior (TA) muscle was investigated following 20, 40, or 60 lengthening contractions (LCs) using an in vivo model of electrical stimulation. Muscles were removed at 0, 1, 3, or 24 h after LCs and assessed for heat shock transcription factor (HSF) activation, heat shock protein (HSP) content, and/or morphological evidence of muscle fibre damage. When compared with the first muscle contraction, peak muscle torque was reduced by 26% (p < 0.05) after 20 LCs and further reduced to 56% and 60% (p < 0.001) after 40 and 60 LCs, respectively. Following 60 LCs, HSF activation was detected at 0, 1, and 3 h but was undetectable at 24 h. Hsp72 content was elevated at 24 h after 20 LCs (2.34 ± 0.37 fold, p < 0.05), 40 LCs (3.02 ± 0.31 fold, p < 0.01), and 60 LCs (3.37 ± 0.21 fold, p < 0.001). Hsp25 content increased after 40 (2.36 ± 0.24 fold, p < 0.01) and 60 LCs (2.80 ± 0.37 fold, p < 0.01). Morphological assessment of TA morphology revealed that very few fibres were damaged following 20 LCs while multiple sets of LCs (40 and 60) caused greater amounts of fibre damage. Electron microscopy showed disrupted Z-lines and sarcomeres were detectable in some muscles fibres following 20 LCs but were more prevalent and severe in muscles subjected to 40 or 60 LCs. These results suggest LCs elevate HSP content by an HSF-mediated mechanism (60 LC) and a single set of 20 LCs is capable of increasing muscle HSP content without causing significant muscle fibre damage.

Heat Shock Protein 27 in Chronic Allograft Nephropathy: A Local Stress Response

2005 ◽  
Vol 79 (12) ◽  
pp. 1645-1657 ◽  
Author(s):  
Arjang Djamali ◽  
Shannon Reese ◽  
Terry Oberley ◽  
Debra Hullett ◽  
Bryan Becker
Keyword(s):  
Stress Response ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Local Stress ◽  
Heat Shock Protein 27 ◽  
Chronic Allograft Nephropathy

765: Modified Expression of Heat Shock Protein 27 in Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 203-203
Author(s):  
Cecilia Sarto ◽  
Paolo Favini ◽  
Cristina Valsecchi ◽  
Stefano Casellato ◽  
Fulvio Magni ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Heat Shock Protein 27

Protektive Wirkung von Heat Shock Protein 27 in der Magenmukosa

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
M Ebert ◽  
C Schäfer ◽  
J Hoffmann ◽  
C Kubisch ◽  
G Treiber ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Protektive Wirkung
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