scholarly journals Ric-3 Promotes Functional Expression of the Nicotinic Acetylcholine Receptor α7 Subunit in Mammalian Cells

2004 ◽  
Vol 280 (2) ◽  
pp. 1257-1263 ◽  
Author(s):  
Mark E. Williams ◽  
Bill Burton ◽  
Arturo Urrutia ◽  
Anatoly Shcherbatko ◽  
Laura E. Chavez-Noriega ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Mammalian Cells ◽  
Functional Expression ◽  
Nicotinic Acetylcholine ◽  
Α7 Subunit

RIC-3 Enhances Functional Expression of Multiple Nicotinic Acetylcholine Receptor Subtypes in Mammalian Cells

2005 ◽  
Vol 68 (5) ◽  
pp. 1431-1438 ◽  
Author(s):  
Stuart J. Lansdell ◽  
Veronica J. Gee ◽  
Patricia C. Harkness ◽  
Anne I. Doward ◽  
Elizabeth R. Baker ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Mammalian Cells ◽  
Functional Expression ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine

scholarly journals Mode of Action of Neonicotinoid Insecticides Imidacloprid and Thiacloprid to the Cockroach Pameα7 Nicotinic Acetylcholine Receptor

2021 ◽  
Vol 22 (18) ◽  
pp. 9880
Author(s):  
Alison Cartereau ◽  
Emiliane Taillebois ◽  
Jean-Yves Le Questel ◽  
Steeve H. Thany
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Partial Agonist ◽  
Functional Expression ◽  
Binding Pocket ◽  
Xenopus Laevis Oocytes ◽  
Nicotinic Acetylcholine ◽  
Neonicotinoid Insecticides ◽  
Neonicotinoid Insecticide ◽  
Inward Currents

The functional expression of the cockroach Pameα7 nicotinic acetylcholine receptor subunit has been previously studied, and was found to be able to form a homomeric receptor when expressed in Xenopus laevis oocytes. In this study, we found that the neonicotinoid insecticide imidacloprid is unable to activate the cockroach Pameα7 receptor, although thiacloprid induces low inward currents, suggesting that it is a partial agonist. In addition, the co-application or 5 min pretreatment with 10 µM imidacloprid increased nicotine current amplitudes, while the co-application or 5 min pretreatment with 10 µM thiacloprid decreased nicotine-evoked current amplitudes by 54% and 28%, respectively. This suggesting that these two representatives of neonicotinoid insecticides bind differently to the cockroach Pameα7 receptor. Interestingly, the docking models demonstrate that the orientation and interactions of the two insecticides in the cockroach Pameα7 nAChR binding pocket are very similar. Electrophysiological results have provided evidence to suggest that imidacloprid and thiacloprid could act as modulators of the cockroach Pameα7 receptors.

scholarly journals RETRACTED: Nicotinic acetylcholine receptor α7 subunit maybe a risk factor of seizure susceptibility

2019 ◽  
Vol 704 ◽  
pp. 15-20 ◽  
Author(s):  
Xu Chen ◽  
Ying Zhang ◽  
Rui-Dong Cheng ◽  
Jie Zhang ◽  
Jue-Bao Li ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Seizure Susceptibility ◽  
Nicotinic Acetylcholine ◽  
Α7 Subunit

scholarly journals Sequence and functional expression of a single alpha subunit of an insect nicotinic acetylcholine receptor.

1990 ◽  
Vol 9 (13) ◽  
pp. 4391-4398 ◽  
Author(s):  
J. Marshall ◽  
S. D. Buckingham ◽  
R. Shingai ◽  
G. G. Lunt ◽  
M. W. Goosey ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Functional Expression ◽  
Alpha Subunit ◽  
Nicotinic Acetylcholine
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