scholarly journals Non-muscle Myosin II and Myosin Light Chain Kinase Are Downstream Targets for Vasopressin Signaling in the Renal Collecting Duct

2004 ◽  
Vol 279 (47) ◽  
pp. 49026-49035 ◽  
Author(s):  
Chung-Lin Chou ◽  
Birgitte M. Christensen ◽  
Sebastian Frische ◽  
Henrik Vorum ◽  
Ravi A. Desai ◽  
...  
Keyword(s):  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Collecting Duct ◽  
Myosin Ii ◽  
Downstream Targets ◽  
Renal Collecting Duct ◽  
Muscle Myosin

scholarly journals Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction

2020 ◽  
Vol 11 ◽  
Author(s):  
Jie Sun ◽  
Yan-Ning Qiao ◽  
Tao Tao ◽  
Wei Zhao ◽  
Li-Sha Wei ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Initial Phase ◽  
Myosin Light Chain ◽  
Myosin Ii ◽  
Smooth Muscle Contraction ◽  
Myosin Regulatory Light Chain ◽  
Gene Encoding ◽  
Muscle Myosin

Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined. In this report, we assessed their roles by analyzing mice deficient of Myl9, a gene encoding the SM myosin regulatory light chain (SM RLC). We find that global Myl9-deficient bladders contracted with an apparent sustained phase, despite no initial phase. This sustained contraction was mediated by NM myosin RLC (NM RLC) phosphorylation by myosin light chain kinase (MLCK). NM myosin II was expressed abundantly in the uterus and young mice bladders, of which the force was accordingly sensitive to NM myosin inhibition. Our findings reveal distinct roles of SM RLC and NM RLC in SM contraction.

scholarly journals Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates

2016 ◽  
Vol 34 (7) ◽  
pp. 469-474 ◽  
Author(s):  
Diego B. Alcala ◽  
Brian D. Haldeman ◽  
Richard K. Brizendine ◽  
Agata K. Krenc ◽  
Josh E. Baker ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Steady State ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Myosin Ii ◽  
Smooth Muscle Myosin ◽  
Nonmuscle Myosin ◽  
Steady State Kinetics ◽  
Muscle Myosin
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