scholarly journals Role of Protein Kinase C Isoforms in the Regulation of Interleukin-13-induced 15-Lipoxygenase Gene Expression in Human Monocytes

2004 ◽  
Vol 279 (16) ◽  
pp. 15954-15960 ◽  
Author(s):  
Bo Xu ◽  
Ashish Bhattacharjee ◽  
Biswajit Roy ◽  
Gerald M. Feldman ◽  
Martha K. Cathcart
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Monocytes ◽  
Interleukin 13 ◽  
Kinase C ◽  
Lipoxygenase Gene ◽  
Protein Kinase C Isoforms

scholarly journals Downregulation of c-fms gene expression in human monocytes treated with phorbol esters and colony-stimulating factor 1

Blood ◽  
1989 ◽  
Vol 74 (1) ◽  
pp. 123-129 ◽  
Author(s):  
E Sariban ◽  
K Imamura ◽  
M Sherman ◽  
V Rothwell ◽  
P Pantazis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Esters ◽  
Constitutive Expression ◽  
Human Monocytes ◽  
Colony Stimulating Factor ◽  
Protein Levels ◽  
Kinase C ◽  
Stimulating Factor

Abstract The colony-stimulating factor-1 (CSF-1) regulates survival, growth, and differentiation of monocytes by binding to a single class of high- affinity receptors. The CSF-1 receptor is identical to the product of the c-fms protooncogene. The present studies monitored the effects of TPA and CSF-1 on c-fms gene expression in human monocytes. The results demonstrate that TPA downmodulates the constitutive expression of c-fms mRNA to low but detectable levels. Treatment of human monocytes with TPA was similarly associated with decreases in levels of the 138- and 125-Kd c-fms-encoded proteins. However, the kinetics of c-fms protein downmodulation indicated independent effects of TPA on c-fms expression at the RNA and protein levels. Furthermore, c-fms protein levels subsequently recovered despite persistently low levels of c-fms mRNA. Although previous studies demonstrated that c-fms protein is down- regulated in the presence of CSF-1, the present results indicate that CSF-1 also downregulates levels of c-fms mRNA. Moreover, the results indicate that CSF-1 increases protein kinase C activity in the membrane fraction. Together, these findings suggest that c-fms gene expression is differentially regulated at both the RNA and protein levels after activation of protein kinase C in human monocytes treated with TPA and CSF-1.

Role of Protein Kinase C Isoforms in Rat Epididymal Microvascular Endothelial Barrier Function

2003 ◽  
Vol 28 (5) ◽  
pp. 626-636 ◽  
Author(s):  
Elizabeth O. Harrington ◽  
Jodi L. Brunelle ◽  
Christopher J. Shannon ◽  
Eric S. Kim ◽  
Kirstin Mennella ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Barrier Function ◽  
Endothelial Barrier ◽  
Endothelial Barrier Function ◽  
Kinase C ◽  
Microvascular Endothelial ◽  
Protein Kinase C Isoforms

Nocardia fractions, NLD and NWSM, induce tumor necrosis factor-α secretion in human monocytes: Role of protein kinase C

1993 ◽  
Vol 23 (7) ◽  
pp. 1582-1587 ◽  
Author(s):  
Jean Louis Mege ◽  
Thiery Jacob ◽  
Pierre Bongrand ◽  
Christian Capo ◽  
Evguenine B. Myssiakine ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Monocytes ◽  
Kinase C ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Vitamin E activates CRABP-II gene expression in cultured human fibroblasts, role of protein kinase C

FEBS Letters ◽  
2004 ◽  
Vol 569 (1-3) ◽  
pp. 240-244 ◽  
Author(s):  
Amparo Gimeno ◽  
Rosa Zaragozá ◽  
Juan R Viña ◽  
Vicente J Miralles
Keyword(s):  
Gene Expression ◽  
Protein Kinase C ◽  
Vitamin E ◽  
Protein Kinase ◽  
Human Fibroblasts ◽  
Kinase C ◽  
Cultured Human Fibroblasts ◽  
Crabp Ii

Role of protein kinase C in induction of gene expression and inhibition of cell proliferation by interferon alpha

1992 ◽  
Vol 209 (3) ◽  
pp. 813-822 ◽  
Author(s):  
Robert I. JAMES ◽  
Juan MENAYA ◽  
Kati HUDSON ◽  
Vinod DEVALIA ◽  
Jonathan RYVES ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Interferon Alpha ◽  
Kinase C
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