scholarly journals Involvement of Glycosylphosphatidylinositol-linked Ceruloplasmin in the Copper/Zinc-Nitric Oxide-dependent Degradation of Glypican-1 Heparan Sulfate in Rat C6 Glioma Cells

2004 ◽  
Vol 279 (13) ◽  
pp. 12918-12923 ◽  
Author(s):  
Katrin Mani ◽  
Fang Cheng ◽  
Birgitta Havsmark ◽  
Samuel David ◽  
Lars-Åke Fransson
Keyword(s):  
Nitric Oxide ◽  
Heparan Sulfate ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Copper Zinc ◽  
Rat C6 Glioma

Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

2008 ◽  
Vol 62 (1) ◽  
pp. 315-321 ◽  
Author(s):  
Douglas L. Feinstein ◽  
Elena Galea ◽  
Steven Roberts ◽  
Henrik Berquist ◽  
Hong Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Oxide Synthase ◽  
Rat C6 Glioma

scholarly journals Sensitivity of the Natriuretic Peptide/cGMP System to Hyperammonaemia in Rat C6 Glioma Cells and GPNT Brain Endothelial Cells

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 398
Author(s):  
Jacob T. Regan ◽  
Samantha M. Mirczuk ◽  
Christopher J. Scudder ◽  
Emily Stacey ◽  
Sabah Khan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Natriuretic Peptide ◽  
Glioma Cells ◽  
C6 Glioma ◽  
Nitric Oxide Donor ◽  
C6 Glioma Cells ◽  
Brain Endothelial Cells ◽  
C6 Cells ◽  
Rat C6 Glioma

C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated in the regulation of neurogenesis, axonal bifurcation, as well as learning and memory. Several neurological disorders result in toxic concentrations of ammonia (hyperammonaemia), which can adversely affect astrocyte function. However, the relationship between CNP and hyperammonaemia is poorly understood. Here, we examine the molecular and pharmacological control of CNP in rat C6 glioma cells and rat GPNT brain endothelial cells, under conditions of hyperammonaemia. Concentration-dependent inhibition of C6 glioma cell proliferation by hyperammonaemia was unaffected by CNP co-treatment. Furthermore, hyperammonaemia pre-treatment (for 1 h and 24 h) caused a significant inhibition in subsequent CNP-stimulated cGMP accumulation in both C6 and GPNT cells, whereas nitric-oxide-dependent cGMP accumulation was not affected. CNP-stimulated cGMP efflux from C6 glioma cells was significantly reduced under conditions of hyperammonaemia, potentially via a mechanism involving changed in phosphodiesterase expression. Hyperammonaemia-stimulated ROS production was unaffected by CNP but enhanced by a nitric oxide donor in C6 cells. Extracellular vesicle production from C6 cells was enhanced by hyperammonaemia, and these vesicles caused impaired CNP-stimulated cGMP signalling in GPNT cells. Collectively, these data demonstrate functional interaction between CNP signalling and hyperammonaemia in C6 glioma and GPNT cells, but the exact mechanisms remain to be established.

scholarly journals Prolactin Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

2002 ◽  
Vol 73 (6) ◽  
pp. 2272-2277 ◽  
Author(s):  
Giuseppina Mattace Raso ◽  
Rosaria Meli ◽  
Oreste Gualillo ◽  
Maria Pacilio ◽  
Raffaele Di Carlo
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Oxide Synthase ◽  
Rat C6 Glioma
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