scholarly journals Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage Clearance of Apoptotic Cells by Preventing Phosphatidylserine Oxidation

2003 ◽  
Vol 279 (7) ◽  
pp. 6056-6064 ◽  
Author(s):  
Yulia Y. Tyurina ◽  
F. Behice Serinkan ◽  
Vladimir A. Tyurin ◽  
Vidisha Kini ◽  
Jack C. Yalowich ◽  
...  
Keyword(s):  
Apoptotic Cells ◽  
Phosphatidylserine Externalization

C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1

2007 ◽  
Vol 9 (5) ◽  
pp. 541-549 ◽  
Author(s):  
Xiaochen Wang ◽  
Jin Wang ◽  
Keiko Gengyo-Ando ◽  
Lichuan Gu ◽  
Chun-Ling Sun ◽  
...  
Keyword(s):  
Apoptotic Cells ◽  
C Elegans ◽  
Phospholipid Scramblase ◽  
Phosphatidylserine Externalization

Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine

2003 ◽  
Vol 285 (1) ◽  
pp. L1-L17 ◽  
Author(s):  
V. E. Kagan ◽  
G. G. Borisenko ◽  
B. F. Serinkan ◽  
Y. Y. Tyurina ◽  
V. A. Tyurin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Inflammatory Responses ◽  
Apoptotic Cells ◽  
Radical Intermediates ◽  
Phosphatidylserine Externalization ◽  
Phospholipid Asymmetry ◽  
Lung Physiology ◽  
Macrophage Receptors

Programmed cell death (apoptosis) functions as a mechanism to eliminate unwanted or irreparably damaged cells ultimately leading to their orderly phagocytosis in the absence of calamitous inflammatory responses. Recent studies have demonstrated that the generation of free radical intermediates and subsequent oxidative stress are implicated as part of the apoptotic execution process. Oxidative stress may simply be an unavoidable yet trivial byproduct of the apoptotic machinery; alternatively, intermediates or products of oxidative stress may act as essential signals for the execution of the apoptotic program. This review is focused on the specific role of oxidative stress in apoptotic signaling, which is realized via phosphatidylserine-dependent pathways leading to recognition of apoptotic cells and their effective clearance. In particular, the mechanisms involved in selective phosphatidylserine oxidation in the plasma membrane during apoptosis and its association with disturbances of phospholipid asymmetry leading to phosphatidylserine externalization and recognition by macrophage receptors are at the center of our discussion. The putative importance of this oxidative phosphatidylserine signaling in lung physiology and disease are also discussed.

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