scholarly journals Reduced Folate Carrier Gene Silencing in Multiple Antifolate-resistant Tumor Cell Lines Is Due to a Simultaneous Loss of Function of Multiple Transcription Factors but Not Promoter Methylation

2003 ◽  
Vol 279 (1) ◽  
pp. 374-384 ◽  
Author(s):  
Lilah Rothem ◽  
Michal Stark ◽  
Yotam Kaufman ◽  
Lior Mayo ◽  
Yehuda G. Assaraf
Keyword(s):  
Transcription Factors ◽  
Tumor Cell ◽  
Gene Silencing ◽  
Cell Lines ◽  
Promoter Methylation ◽  
Reduced Folate Carrier ◽  
Tumor Cell Lines ◽  
Loss Of Function ◽  
Simultaneous Loss

Characterization of the promoter for the α3 integrin gene in various tumor cell lines: Roles of the Ets- and Sp-family of transcription factors

2006 ◽  
Vol 97 (3) ◽  
pp. 530-543 ◽  
Author(s):  
Kouji Katabami ◽  
Takumi Kato ◽  
Rikio Sano ◽  
Masaharu Ogura ◽  
Hiromi Mizuno ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Integrin Gene ◽  
Α3 Integrin

WEE1 gene silencing can reduce Bcl2 expression in brain tumor cell lines

2011 ◽  
Vol 44 (13) ◽  
pp. S205
Author(s):  
Hosseini Ahmad ◽  
Rahnama Susan ◽  
Jaberipour Mansooreh ◽  
Habib-Agahi Mojtaba
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Gene Silencing ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Brain Tumor Cell ◽  
Bcl2 Expression

scholarly journals CancerGD: a resource for identifying and interpreting genetic dependencies in cancer

2016 ◽  
Author(s):  
Stephen Bridgett ◽  
James Campbell ◽  
Christopher J. Lord ◽  
Colm J. Ryan
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Large Scale ◽  
Interaction Networks ◽  
Tumor Cell Lines ◽  
Loss Of Function ◽  
Genetic Screens ◽  
Functional Interaction ◽  
Genetic Aberrations ◽  
Precision Therapeutics

AbstractGenes whose function is selectively essential in the presence of cancer associated genetic aberrations represent promising targets for the development of precision therapeutics. Here we present CancerGD (www.cancergd.org), a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks.

The multiple promoter methylation profile of PR gene and ERα gene in tumor cell lines

Life Sciences ◽  
2003 ◽  
Vol 73 (15) ◽  
pp. 1963-1972 ◽  
Author(s):  
Ze-Jun Liu ◽  
Masato Maekawa ◽  
Toshinobu Horii ◽  
Motoki Morita
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Promoter Methylation ◽  
Methylation Profile ◽  
Tumor Cell Lines ◽  
Multiple Promoter

Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

1983 ◽  
Vol 50 (03) ◽  
pp. 726-730 ◽  
Author(s):  
Hamid Al-Mondhiry ◽  
Virginia McGarvey ◽  
Kim Leitzel
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Human Tumor ◽  
Human Platelets ◽  
Factor Vii ◽  
Coagulation System ◽  
Breast Adenocarcinoma ◽  
Activate Factor ◽  
Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

Differential Increases in Glutathione S-Transferase Activities in a Range of Multidrug-Resistant Human Tumor Cell Lines

1989 ◽  
Vol 1 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Richard D. H. Whelan ◽  
Louise K. Hosking ◽  
Alan J. Townsend ◽  
Kenneth H. Cowan ◽  
Bridget T. Hill
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Multidrug Resistant ◽  
Tumor Cell Lines ◽  
Glutathione S Transferase ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines
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