scholarly journals Differential Activation of “Social” and “Solitary” Variants of the Caenorhabditis elegans G Protein-coupled Receptor NPR-1 by Its Cognate Ligand AF9

2003 ◽  
Vol 278 (36) ◽  
pp. 33724-33729 ◽  
Author(s):  
Teresa M. Kubiak ◽  
Martha J. Larsen ◽  
Susan C. Nulf ◽  
Marjorie R. Zantello ◽  
Katherine J. Burton ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Differential Activation ◽  
G Protein Coupled

scholarly journals Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽  
2020 ◽  
Vol 19 (6) ◽  
Author(s):  
Anubhuti Dixit ◽  
Anjali Sandhu ◽  
Souvik Modi ◽  
Meghana Shashikanth ◽  
Sandhya P. Koushika ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Neuronal Control ◽  
G Protein Coupled

scholarly journals Identification of a Conserved, Orphan G Protein-Coupled Receptor Required for Efficient Pathogen Clearance in Caenorhabditis elegans

2019 ◽  
Vol 87 (4) ◽  
Author(s):  
Alexandra Anderson ◽  
Yee Lian Chew ◽  
William Schafer ◽  
Rachel McMullan
Keyword(s):  
Caenorhabditis Elegans ◽  
Immune Responses ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled Receptor ◽  
Content Type ◽  
C Elegans ◽  
Host Immune Responses ◽  
Pathogen Clearance ◽  
G Protein Coupled

ABSTRACT G protein-coupled receptors contribute to host defense across the animal kingdom, transducing many signals involved in both vertebrate and invertebrate immune responses. While it has become well established that the nematode worm Caenorhabditis elegans triggers innate immune responses following infection with numerous bacterial, fungal, and viral pathogens, the mechanisms by which C. elegans recognizes these pathogens have remained somewhat more elusive. C. elegans G protein-coupled receptors have been implicated in recognizing pathogen-associated damage and activating downstream host immune responses. Here we identify and characterize a novel G protein-coupled receptor required to regulate the C. elegans response to infection with Microbacterium nematophilum. We show that this receptor, which we designate pathogen clearance-defective receptor 1 (PCDR-1), is required for efficient pathogen clearance following infection. PCDR-1 acts upstream of multiple G proteins, including the C. elegans Gαq ortholog, EGL-30, in rectal epithelial cells to promote pathogen clearance via a novel mechanism.

scholarly journals Differential Activation of Cultured Neonatal Cardiomyocytes by PlasmalemmalVersusIntracellular G Protein-coupled Receptor 55

2013 ◽  
Vol 288 (31) ◽  
pp. 22481-22492 ◽  
Author(s):  
Justine Yu ◽  
Elena Deliu ◽  
Xue-Quian Zhang ◽  
Nicholas E. Hoffman ◽  
Rhonda L. Carter ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Differential Activation ◽  
Neonatal Cardiomyocytes ◽  
G Protein Coupled

scholarly journals G protein–coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress

2020 ◽  
Vol 26 (1) ◽  
pp. 187-197
Author(s):  
Stacy A. Henry ◽  
Selina Crivello ◽  
Tina M. Nguyen ◽  
Magdalena Cybulska ◽  
Ngoc S. Hoang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles in Caenorhabditis elegans

2021 ◽  
Author(s):  
Yunhan Yang ◽  
Wenting Dong ◽  
Qiuli Wu ◽  
Dayong Wang
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Polystyrene Nanoparticles ◽  
G Protein Coupled

The deposition of certain amount of nanopolystyrene (NPS) could be observed in gonad of Caenorhabditis elegans. However, we still know little about the response of germline to NPS exposure. In...

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