Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2

Kyung Song; Susan C. Cornelius; Michael Reiss; David Danielpour

doi:10.1074/jbc.m304583200

Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2

Journal of Biological Chemistry ◽

10.1074/jbc.m304583200 ◽

2003 ◽

Vol 278 (40) ◽

pp. 38342-38351 ◽

Cited By ~ 76

Author(s):

Kyung Song ◽

Susan C. Cornelius ◽

Michael Reiss ◽

David Danielpour

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Transcriptional Responses ◽

Factor I ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Insulin like growth factor-I induces limited association of phosphatidylinositol 3-kinase to its receptor.

Endocrinology ◽

10.1210/endo.130.3.1311242 ◽

1992 ◽

Vol 130 (3) ◽

pp. 1490-1498 ◽

Cited By ~ 2

Author(s):

K Yamamoto ◽

E G Lapetina ◽

C P Moxham

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Estradiol-17β, Insulin-Like Growth Factor-I, and Luteinizing Hormone Inhibit Secretion of Transforming Growth Factor β by Rat Ovarian Theca-Interstitial Cells1

Biology of Reproduction ◽

10.1095/biolreprod53.3.627 ◽

1995 ◽

Vol 53 (3) ◽

pp. 627-635 ◽

Cited By ~ 17

Author(s):

Denis A. Magoffin ◽

Debbie Hubert-Leslie ◽

Rob J. Zachow

Keyword(s):

Growth Factor ◽

Luteinizing Hormone ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Insulin Like Growth Factor ◽

Factor I ◽

Growth Factor I ◽

Estradiol 17Β

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The Phosphatidylinositol-3 kinase Pathway Is Not Essential for Insulin-like Growth Factor I Receptor-mediated Clonogenic Radioresistance

Journal of Radiation Research ◽

10.1269/jrr.43.325 ◽

2002 ◽

Vol 43 (3) ◽

pp. 325-329 ◽

Cited By ~ 3

Author(s):

DONG YU ◽

HIROSHI WATANABE ◽

HITOSHI SHIBUYA ◽

MASAHIKO MIURA

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Growth Factor I ◽

Kinase Pathway ◽

Phosphatidylinositol 3

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Insulin-Like Growth Factor-I Inhibits Dexamethasone-Induced Catabolism in Cultured L6 Myotubes by Activation of Phosphatidylinositol 3-Kinase

Journal of Burn Care & Rehabilitation ◽

10.1097/00004630-200303002-00195 ◽

2003 ◽

Vol 24 ◽

pp. S140

Author(s):

&NA;

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

L6 Myotubes ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Insulin like growth factor-I induces limited association of phosphatidylinositol 3-kinase to its receptor

Endocrinology ◽

10.1210/en.130.3.1490 ◽

1992 ◽

Vol 130 (3) ◽

pp. 1490-1498 ◽

Cited By ~ 10

Author(s):

K. Yamamoto

Keyword(s):

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Effects of Insulin-Like Growth Factor I on Transforming Growth Factor β1 Induced Chondrogenesis of Synovium-Derived Mesenchymal Stem Cells Cultured in a Polyglycolic Acid Scaffold

Cells Tissues Organs ◽

10.1159/000095509 ◽

2006 ◽

Vol 183 (2) ◽

pp. 55-61 ◽

Cited By ~ 27

Author(s):

Koichiro Sakimura ◽

Tomoko Matsumoto ◽

Chikara Miyamoto ◽

Makoto Osaki ◽

Hiroyuki Shindo

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Polyglycolic Acid ◽

Insulin Like Growth Factor ◽

Factor I ◽

Growth Factor I ◽

Cells Cultured

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Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways Are Not Sufficient for Insulin-Like Growth Factor I-Induced Mitogenesis and Tumorigenesis

Endocrinology ◽

10.1210/endo.138.6.5215 ◽

1997 ◽

Vol 138 (6) ◽

pp. 2552-2558 ◽

Cited By ~ 15

Author(s):

Angus G. Scrimgeour ◽

Vicky A. Blakesley ◽

Bethel S. Stannard ◽

Derek LeRoith

Keyword(s):

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Mitogen Activated Protein ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

Journal of Biological Chemistry ◽

10.1074/jbc.m112.393074 ◽

2012 ◽

Vol 287 (35) ◽

pp. 29713-29721 ◽

Cited By ~ 19

Author(s):

Toshiaki Fukushima ◽

Yusaku Nakamura ◽

Daisuke Yamanaka ◽

Takashi Shibano ◽

Kazuhiro Chida ◽

...

Keyword(s):

Cell Proliferation ◽

Growth Factor ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Pi3k Activity ◽

Igf I ◽

Growth Factor I ◽

Phosphatidylinositol 3

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Immunohistochemical localization of transforming growth factor-β and insulin-like growth factor-I in asbestosis in the sheep model

International Archives of Occupational and Environmental Health ◽

10.1007/s004200050132 ◽

1997 ◽

Vol 69 (3) ◽

pp. 157-164 ◽

Cited By ~ 19

Author(s):

Theodore C. Lee ◽

Leslie I. Gold ◽

Joan Reibman ◽

Christopher Aston ◽

Raymond Bégin ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Immunohistochemical Localization ◽

Insulin Like Growth Factor ◽

Sheep Model ◽

Factor I ◽

Growth Factor I

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Possible Involvement of Phosphatidylinositol 3-Kinase/Akt Pathway in Insulin-like Growth Factor-I-induced Alkaline Phosphatase Activity in Osteoblasts

Hormone and Metabolic Research ◽

10.1055/s-2005-861468 ◽

2005 ◽

Vol 37 (5) ◽

pp. 270-274 ◽

Cited By ~ 19

Author(s):

T. Noda ◽

H. Tokuda ◽

M. Yoshida ◽

E. Yasuda ◽

Y. Hanai ◽

...

Keyword(s):

Alkaline Phosphatase ◽

Growth Factor ◽

Phosphatase Activity ◽

Alkaline Phosphatase Activity ◽

Akt Pathway ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Growth Factor I ◽

Phosphatidylinositol 3

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