scholarly journals Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes

2003 ◽  
Vol 278 (36) ◽  
pp. 34709-34716 ◽  
Author(s):  
Jae-Won Soh ◽  
I. Bernard Weinstein
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cyclin D1 ◽  
Transcriptional Control ◽  
Kinase C

scholarly journals Protein Kinase C Isoforms Involved in the Transcriptional Activation of Cyclin D1 by Transforming Ha-Ras

2001 ◽  
Vol 276 (46) ◽  
pp. 42834-42842 ◽  
Author(s):  
Sonja Kampfer ◽  
Michaela Windegger ◽  
Franz Hochholdinger ◽  
Wolfgang Schwaiger ◽  
Richard G. Pestell ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cyclin D1 ◽  
Transcriptional Activation ◽  
Kinase C ◽  
Protein Kinase C Isoforms

scholarly journals Protein Kinase C α Signaling Inhibits Cyclin D1 Translation in Intestinal Epithelial Cells

2006 ◽  
Vol 281 (21) ◽  
pp. 14596-14603 ◽  
Author(s):  
A. Asli Hizli ◽  
Adrian R. Black ◽  
Marybeth A. Pysz ◽  
Jennifer D. Black
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Epithelial Cells ◽  
Cyclin D1 ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Kinase C

Abstract P254: Protein Kinase C Binding Protein 1 Inhibits Hypoxia-Inducible Factor 1 Action in the Heart

2011 ◽  
Vol 109 (suppl_1) ◽  
Author(s):  
Chad B Walton ◽  
David Veal ◽  
Chrisy Mafnas ◽  
Keith A MacCannell ◽  
Cynthia D Anderson ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Transcriptional Control ◽  
Binding Protein ◽  
Hypoxia Inducible Factor ◽  
Direct Interaction ◽  
Physiological Data ◽  
Stable Form ◽  
Hypoxia Inducible Factor 1 ◽  
Kinase C

The response to hypoxia in tissues is regulated by the heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1). We have investigated the transcriptional effects of hypoxia-inducible factor 1 alpha (HIF-1α) in the heart by expressing an oxygen-stable form of HIF-1α in cardiac myocytes of transgenic mice. The result in most cases is regulation of an expected panoply of genes that restore homeostasis during hypoxia, with corresponding phenotypic changes including contractile dysfunction and increased capillary density. In mice that do not show this phenotype, the mRNA for protein kinase c binding protein 1 isoform 2 (PRKCBP1) was much more abundant, as was the protein, and chromatin immunoprecipitation shows a predominant binding of HIF to the promoter of this gene. Sequencing of the promoter region of the PRKCBP1 gene from the two phenotypes revealed an unexpected 480 bp insert in the HIF-resistant animals containing two canonical HIF binding sites. The protein co-immunoprecipitates with HIF and inhibits HIF transcriptional activity in cell culture. In FVB mice, that contain the promoter insert, PRKCBP is induced by ischemia and co-localizes with HIF in the infarct region. It may be responsible for the greater susceptibility of this strain to heart failure after infarction. We have confirmed with genetic, transcriptional, biochemical, and physiological data that Prkcbp1 inhibits HIF activity through direct interaction, in a mechanism mediated by transcriptional control.

Protein kinase C delta (PKC-δ) regulates post-transcriptional expression of cyclin D1 and Bcl-2 in CaCo-2 cells

2003 ◽  
Vol 124 (4) ◽  
pp. A284
Author(s):  
Sonia R. Cerda ◽  
Greg Cohen ◽  
Christopher M. Moore ◽  
Reba Mustafi ◽  
Marc Bissonnette
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cyclin D1 ◽  
Transcriptional Expression ◽  
Protein Kinase C Delta ◽  
Kinase C
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