scholarly journals Eph B4 Receptor Signaling Mediates Endothelial Cell Migration and Proliferation via the Phosphatidylinositol 3-Kinase Pathway

2002 ◽  
Vol 277 (46) ◽  
pp. 43830-43835 ◽  
Author(s):  
Jena J. Steinle ◽  
Cynthia J. Meininger ◽  
Reza Forough ◽  
Guoyao Wu ◽  
Mack H. Wu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Endothelial Cell Migration ◽  
Receptor Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Cell Migration And Proliferation ◽  
Kinase Pathway ◽  
Phosphatidylinositol 3

Ras, Rac1, and phosphatidylinositol-3-kinase (PI3K) signaling in nitric oxide induced endothelial cell migration

Nitric Oxide ◽  
2015 ◽  
Vol 47 ◽  
pp. 40-51 ◽  
Author(s):  
Roberta Eller-Borges ◽  
Wagner L. Batista ◽  
Paulo E. da Costa ◽  
Rita Tokikawa ◽  
Marli F. Curcio ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Endothelial Cell Migration ◽  
Pi3k Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway

2005 ◽  
Vol 25 (16) ◽  
pp. 6889-6898 ◽  
Author(s):  
John R. Basile ◽  
Talayeh Afkhami ◽  
J. Silvio Gutkind
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Tyrosine Kinase ◽  
Axonal Guidance ◽  
Endothelial Cell Migration ◽  
Akt Pathway ◽  
Tyrosine Kinase Domain ◽  
Phosphatidylinositol 3 Kinase ◽  
Semaphorin 4D ◽  
Phosphatidylinositol 3

ABSTRACT Semaphorins are cell surface and secreted proteins that provide axonal guidance in neuronal tissues and regulate cell motility in many cell types. They act by binding a family of transmembrane receptors known as plexins, which belong to the c-Met family of scatter factor receptors but lack an intrinsic tyrosine kinase domain. Interestingly, we have recently shown that Plexin-B1 is highly expressed in endothelial cells and that its activation by Semaphorin 4D elicits a potent proangiogenic response (J. R. Basile, A. Barac, T. Zhu, K. L. Guan, and J. S. Gutkind, Cancer Res. 64:5212-5224, 2004). In searches for the underlying molecular mechanism, we observed that Semaphorin 4D-stimulated endothelial cell migration requires the activation of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. Surprisingly, we found that Plexin-B1 stimulates PI3K-Akt through the activation of an intracellular tyrosine kinase cascade that involves the sequential activation of PYK2 and Src. This results in the tyrosine phosphorylation of Plexin-B1, the rapid recruitment of a multimeric signaling complex that includes PYK2, Src, and PI3K to Plexin-B1 and the activation of Akt. These findings suggest that Plexin-B1 may achieve its numerous physiological functions through the direct activation of intracellular tyrosine kinase cascades.

scholarly journals AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation

2016 ◽  
Vol 105 ◽  
pp. 103-108 ◽  
Author(s):  
Jing Jia ◽  
Taiyang Ye ◽  
Pengfei Cui ◽  
Qian Hua ◽  
Huiyan Zeng ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Endothelial Cell Migration ◽  
Cell Migration And Proliferation
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