scholarly journals Activation of pyk2/Related Focal Adhesion Tyrosine Kinase and Focal Adhesion Kinase in Cardiac Remodeling

2002 ◽  
Vol 277 (47) ◽  
pp. 45203-45210 ◽  
Author(s):  
Jaime Melendez ◽  
Sara Welch ◽  
Erik Schaefer ◽  
Christine S. Moravec ◽  
Shalom Avraham ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cardiac Remodeling

scholarly journals Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 ◽  
Vol 270 (36) ◽  
pp. 21206-21219 ◽  
Author(s):  
Hiroko Sasaki ◽  
Kazuko Nagura ◽  
Masaho Ishino ◽  
Hirotoshi Tobioka ◽  
Kiyoshi Kotani ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Kinase Subfamily ◽  
Novel Protein

Focal adhesion kinase: at the crossroads of signal transduction

1997 ◽  
Vol 110 (4) ◽  
pp. 401-407 ◽  
Author(s):  
D. Ilic ◽  
C.H. Damsky ◽  
T. Yamamoto
Keyword(s):  
Signal Transduction ◽  
Extracellular Matrix ◽  
Cell Migration ◽  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Signaling Pathways ◽  
Focal Adhesion ◽  
Nonreceptor Tyrosine Kinase ◽  
Definitive Evidence ◽  
Multiple Signaling

Morphogenetic processes during development, including cell migration, depend on signals from both the extracellular matrix (ECM) and soluble signaling factors. Extensive evidence has shown that the nonreceptor tyrosine kinase, focal adhesion kinase (FAK), is activated in response to both kind of signal. The most definitive evidence that FAK is directly downstream of signals initiated by the ECM comes from comparing the phenotypes of mice deficient for FAK and the ECM molecule, fibronectin: in both cases embryos die at about E8.5 and display almost identical severe vascular and other mesodermal defects. It is now clear that there are additional FAK-like proteins, indicating the existence of a FAK family. Furthermore, FAK is not located at adhesive sites in all cells where it is expressed. This, plus extensive data indicating that FAK becomes activated in response to several soluble signaling factors, suggests that the FAK family may be at the crossroads of multiple signaling pathways that affect cell and developmental processes.

scholarly journals Monitoring focal adhesion kinase phosphorylation dynamics in live cells

The Analyst ◽  
2017 ◽  
Vol 142 (15) ◽  
pp. 2713-2716 ◽  
Author(s):  
Nur P. Damayanti ◽  
Kevin Buno ◽  
Nagarajan Narayanan ◽  
Sherry L. Voytik Harbin ◽  
Meng Deng ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Focal Adhesion Kinase ◽  
Real Time ◽  
Focal Adhesion ◽  
Receptor Tyrosine Kinase ◽  
Live Cells ◽  
Real Time Monitoring ◽  
Cellular Functions ◽  
Focal Adhesion Kinase Phosphorylation ◽  
Kinase Phosphorylation

Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase essential for a diverse set of cellular functions. FAK FLIM-peptide biosensor enables real-time monitoring of FAK phopshorylation activity.

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