scholarly journals The Mutational Specificity of the Dbh Lesion Bypass Polymerase and Its Implications

2002 ◽  
Vol 277 (31) ◽  
pp. 28157-28166 ◽  
Author(s):  
Olga Potapova ◽  
Nigel D. F. Grindley ◽  
Catherine M. Joyce
Keyword(s):  
Lesion Bypass ◽  
Mutational Specificity ◽  
Bypass Polymerase

scholarly journals Identification of an Unfolding Intermediate for a DNA Lesion Bypass Polymerase

2012 ◽  
Vol 25 (7) ◽  
pp. 1531-1540 ◽  
Author(s):  
Shanen M. Sherrer ◽  
Brian A. Maxwell ◽  
Lindsey R. Pack ◽  
Kevin A. Fiala ◽  
Jason D. Fowler ◽  
...  
Keyword(s):  
Lesion Bypass ◽  
Dna Lesion ◽  
Bypass Polymerase

scholarly journals Coexistence of SOS-Dependent and SOS-Independent Regulation of DNA Repair Genes in Radiation-Resistant Deinococcus Bacteria

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 924
Author(s):  
Laurence Blanchard ◽  
Arjan de Groot
Keyword(s):  
Dna Repair ◽  
Deinococcus Radiodurans ◽  
Dna Repair Genes ◽  
Lesion Bypass ◽  
Radiation Resistant ◽  
Radiation Induced ◽  
Induced Mutagenesis ◽  
High Doses ◽  
Translesion Polymerases ◽  
Repair Genes

Deinococcus bacteria are extremely resistant to radiation and able to repair a shattered genome in an essentially error-free manner after exposure to high doses of radiation or prolonged desiccation. An efficient, SOS-independent response mechanism to induce various DNA repair genes such as recA is essential for radiation resistance. This pathway, called radiation/desiccation response, is controlled by metallopeptidase IrrE and repressor DdrO that are highly conserved in Deinococcus. Among various Deinococcus species, Deinococcus radiodurans has been studied most extensively. Its genome encodes classical DNA repair proteins for error-free repair but no error-prone translesion DNA polymerases, which may suggest that absence of mutagenic lesion bypass is crucial for error-free repair of massive DNA damage. However, many other radiation-resistant Deinococcus species do possess translesion polymerases, and radiation-induced mutagenesis has been demonstrated. At least dozens of Deinococcus species contain a mutagenesis cassette, and some even two cassettes, encoding error-prone translesion polymerase DnaE2 and two other proteins, ImuY and ImuB-C, that are probable accessory factors required for DnaE2 activity. Expression of this mutagenesis cassette is under control of the SOS regulators RecA and LexA. In this paper, we review both the RecA/LexA-controlled mutagenesis and the IrrE/DdrO-controlled radiation/desiccation response in Deinococcus.

scholarly journals Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

Cell Reports ◽  
2021 ◽  
Vol 36 (4) ◽  
pp. 109440
Author(s):  
María J. Cabello-Lobato ◽  
Cristina González-Garrido ◽  
María I. Cano-Linares ◽  
Ronald P. Wong ◽  
Aurora Yáñez-Vílchez ◽  
...  
Keyword(s):  
Replication Fork ◽  
Gap Filling ◽  
Lesion Bypass ◽  
Physical Interactions

scholarly journals Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase

2008 ◽  
Vol 36 (12) ◽  
pp. 3867-3878 ◽  
Author(s):  
Jessica A. Brown ◽  
Sean A. Newmister ◽  
Kevin A. Fiala ◽  
Zucai Suo
Keyword(s):  
Dna Polymerase ◽  
Lesion Bypass ◽  
Double Base ◽  
Base Lesion ◽  
Y Family
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