scholarly journals Developmental Regulation of Apolipoprotein B mRNA Editing Is an Autonomous Function of Small Intestine Involving Homeobox Gene Cdx1

2002 ◽  
Vol 278 (9) ◽  
pp. 7600-7606 ◽  
Author(s):  
Amy P. Patterson ◽  
Zhigang Chen ◽  
Deborah C. Rubin ◽  
Virginie Moucadel ◽  
Juan Lucio Iovanna ◽  
...  
Keyword(s):  
Small Intestine ◽  
Apolipoprotein B ◽  
Developmental Regulation ◽  
Homeobox Gene ◽  
Mrna Editing ◽  
Autonomous Function

scholarly journals Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase

1999 ◽  
Vol 341 (3) ◽  
pp. 639-645 ◽  
Author(s):  
Mark P. SOWDEN ◽  
Heidi L. COLLINS ◽  
Harold C. SMITH ◽  
Timothy A. GARROW ◽  
Janet D. SPARKS ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Monoclonal Antibodies ◽  
Small Intestine ◽  
Apolipoprotein B ◽  
Rat Hepatocytes ◽  
Mrna Abundance ◽  
Mrna Editing ◽  
Apo B ◽  
Lipoprotein Secretion ◽  
Steady State Levels

The cDNA encoding rat betaine-homocysteine S-methyltransferase (BHMT) was isolated through production of monoclonal antibodies against protein fractions enriched with apolipoprotein B (apo B)-mRNA-editing complexes. BHMT mRNA was expressed predominantly in liver, and also in kidney, but not in small intestine. In stable McArdle RH-7777 (McA) cell lines expressing differing levels of BHMT, the editing efficiency of apo B mRNA was unchanged. Evaluation of apo B-mRNA expression revealed that steady-state levels were increased significantly and in parallel with BHMT protein expression. The highest levels of BHMT mRNA and BHMT enzyme activity expressed in stably transfected McA cells were comparable with those found in rat hepatocytes. In contrast to the changes in apo B-mRNA abundance, levels of other apolipoprotein-encoding mRNAs and several liver-specific and ubiquitously expressed mRNAs were unchanged by BHMT expression. In the cell line expressing the highest level of BHMT, apo B-containing lipoprotein secretion was increased, indicating utilization of increased endogenous message. Results suggest that apo B-mRNA abundance in McA cells is related to the expression of BHMT, an enzyme important in homocysteine metabolism.

scholarly journals Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): structure–function relationships of RNA editing and dimerization

1999 ◽  
Vol 40 (4) ◽  
pp. 623-635 ◽  
Author(s):  
Ba-Bie Teng ◽  
Scott Ochsner ◽  
Qian Zhang ◽  
Kizhake V. Soman ◽  
Paul P. Lau ◽  
...  
Keyword(s):  
Structure Function ◽  
Rna Editing ◽  
Apolipoprotein B ◽  
Mutational Analysis ◽  
Mrna Editing ◽  
Editing Enzyme

scholarly journals Apolipoprotein B mRNA editing. Direct determination of the edited base and occurrence in non-apolipoprotein B-producing cell lines.

1990 ◽  
Vol 265 (36) ◽  
pp. 22446-22452 ◽  
Author(s):  
K Boström ◽  
Z Garcia ◽  
K S Poksay ◽  
D F Johnson ◽  
A J Lusis ◽  
...  
Keyword(s):  
Cell Lines ◽  
Apolipoprotein B ◽  
Direct Determination ◽  
Mrna Editing

Apolipoprotein B mRNA Editing

2018 ◽  
pp. 297-317
Author(s):  
Nicholas O. Davidson
Keyword(s):  
Apolipoprotein B ◽  
Mrna Editing
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