scholarly journals Direct Interaction between Mammalian DNA Polymerase β and Proliferating Cell Nuclear Antigen

2002 ◽  
Vol 277 (34) ◽  
pp. 31115-31123 ◽  
Author(s):  
Padmini S. Kedar ◽  
Soon-Jong Kim ◽  
Anthony Robertson ◽  
Esther Hou ◽  
Rajendra Prasad ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Direct Interaction ◽  
Nuclear Antigen ◽  
Dna Polymerase Β ◽  
Proliferating Cell

scholarly journals Proliferating Cell Nuclear Antigen Binds DNA Polymerase-β and Mediates 1-Methyl-4-Phenylpyridinium-Induced Neuronal Death

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106669 ◽  
Author(s):  
Zhentao Zhang ◽  
Zhaohui Zhang ◽  
Hongcai Wang ◽  
Guoxin Zhang ◽  
Dan Hu ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Neuronal Death ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Dna Polymerase Β ◽  
Proliferating Cell

scholarly journals Direct Interaction of Proliferating Cell Nuclear Antigen with the Small Subunit of DNA Polymerase δ

2002 ◽  
Vol 277 (27) ◽  
pp. 24340-24345 ◽  
Author(s):  
Xiaoqing Lu ◽  
Cheng-Keat Tan ◽  
Jin-Qiu Zhou ◽  
Min You ◽  
L. Michael Carastro ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Direct Interaction ◽  
Small Subunit ◽  
Nuclear Antigen ◽  
Dna Polymerase Δ ◽  
Proliferating Cell

scholarly journals Human DNA Polymerase β, but Not λ, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen

2012 ◽  
Vol 8 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Emmanuele Crespan ◽  
Emanuela Pasi ◽  
Shuhei Imoto ◽  
Ulrich Hübscher ◽  
Marc M. Greenberg ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Dna Polymerase Β ◽  
Human Dna ◽  
Proliferating Cell

Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells

1989 ◽  
Vol 9 (1) ◽  
pp. 57-66
Author(s):  
M Zuber ◽  
E M Tan ◽  
M Ryoji
Keyword(s):  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Living Cells ◽  
Nuclear Antigen ◽  
Plasmid Replication ◽  
Dna Polymerase Delta ◽  
Dna Polymerase Alpha ◽  
Proliferating Cell

Proliferating cell nuclear antigen (PCNA) (also called cyclin) is known to stimulate the activity of DNA polymerase delta but not the other DNA polymerases in vitro. We injected a human autoimmune antibody against PCNA into unfertilized eggs of Xenopus laevis and examined the effects of this antibody on the replication of injected plasmid DNA as well as egg chromosomes. The anti-PCNA antibody inhibited plasmid replication by up to 67%, demonstrating that PCNA is involved in plasmid replication in living cells. This result further implies that DNA polymerase delta is necessary for plasmid replication in vivo. Anti-PCNA antibody alone did not block plasmid replication completely, but the residual replication was abolished by coinjection of a monoclonal antibody against DNA polymerase alpha. Anti-DNA polymerase alpha alone inhibited plasmid replication by 63%. Thus, DNA polymerase alpha is also required for plasmid replication in this system. In similar studies on the replication of egg chromosomes, the inhibition by anti-PCNA antibody was only 30%, while anti-DNA polymerase alpha antibody blocked 73% of replication. We concluded that the replication machineries of chromosomes and plasmid differ in their relative content of DNA polymerase delta. In addition, we obtained evidence through the use of phenylbutyl deoxyguanosine, an inhibitor of DNA polymerase alpha, that the structure of DNA polymerase alpha holoenzyme for chromosome replication is significantly different from that for plasmid replication.

scholarly journals Direct Interaction between Uracil-DNA Glycosylase and a Proliferating Cell Nuclear Antigen Homolog in the CrenarchaeonPyrobaculum aerophilum

2002 ◽  
Vol 277 (25) ◽  
pp. 22271-22278 ◽  
Author(s):  
Hanjing Yang ◽  
Ju-Huei Chiang ◽  
Sorel Fitz-Gibbon ◽  
Michel Lebel ◽  
Alessandro A. Sartori ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Direct Interaction ◽  
Dna Glycosylase ◽  
Nuclear Antigen ◽  
Uracil Dna Glycosylase ◽  
Proliferating Cell

scholarly journals Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase λ and Proliferating Cell Nuclear Antigen 2

2011 ◽  
Vol 23 (2) ◽  
pp. 806-822 ◽  
Author(s):  
Alessandra Amoroso ◽  
Lorenzo Concia ◽  
Caterina Maggio ◽  
Cécile Raynaud ◽  
Catherine Bergounioux ◽  
...  
Keyword(s):  
Dna Damage ◽  
Arabidopsis Thaliana ◽  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Oxidative Dna Damage ◽  
Nuclear Antigen ◽  
Dna Polymerase Λ ◽  
Proliferating Cell
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