scholarly journals Synergistic Transactivation of the Differentiation-dependent Lung Gene Clara Cell Secretory Protein (Secretoglobin 1a1) by the Basic Region Leucine Zipper Factor CCAAT/Enhancer-binding Protein α and the Homeodomain Factor Nkx2.1/Thyroid Transcription Factor-1

2002 ◽  
Vol 277 (40) ◽  
pp. 36970-36977 ◽  
Author(s):  
Tobias N. Cassel ◽  
Tove Berg ◽  
Guntram Suske ◽  
Magnus Nord
Keyword(s):  
Leucine Zipper ◽  
Secretory Protein ◽  
Clara Cell ◽  
Dependent Lung ◽  
Thyroid Transcription Factor 1 ◽  
Clara Cell Secretory Protein ◽  
Thyroid Transcription Factor ◽  
Enhancer Binding Protein ◽  
Transcription Factor 1 ◽  
Basic Region

C/EBP transcription factors in the lung epithelium

2003 ◽  
Vol 285 (4) ◽  
pp. L773-L781 ◽  
Author(s):  
Tobias N. Cassel ◽  
Magnus Nord
Keyword(s):  
Transcription Factors ◽  
Leucine Zipper ◽  
Target Genes ◽  
Secretory Protein ◽  
Clara Cell ◽  
Lung Epithelium ◽  
Differentiation Markers ◽  
Clara Cell Secretory Protein ◽  
P450 Enzyme ◽  
Basic Region

During recent years, the biological roles of CCAAT/enhancer binding proteins (C/EBPs) in the lung have started to be uncovered. C/EBPs form a family within the basic region-leucine zipper class of transcription factors. In the lung epithelium C/EBPα, -β, and -δ are expressed. Lung-specific target genes for these transcription factors include the surfactant proteins A and D, the Clara cell secretory protein, and the P450 enzyme CYP2B1. As more information is gathered, a picture is emerging in which C/EBPα has a role in regulating proliferation as well as differentiation-dependent gene expression, whereas C/EBPβ and -δ, in addition to a partly overlapping role in regulating expression of differentiation markers, also seem to be involved in responses to injury and hormones.

scholarly journals Identification of Thyroid Transcription Factor-1 in C Cells and Parathyroid Cells

Endocrinology ◽  
1998 ◽  
Vol 139 (6) ◽  
pp. 3014-3017 ◽  
Author(s):  
Koichi Suzuki ◽  
Yoshihiko Kobayashi ◽  
Ryohei Katoh ◽  
Leonard D. Kohn ◽  
Akira Kawaoi
Keyword(s):  
Transcription Factor ◽  
C Cells ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1
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