Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response

Conggang Zhang; Zeyu Liu; Eric Bunker; Adrian Ramirez; Schuyler Lee; Yinghua Peng; Aik-Choon Tan; S. Gail Eckhardt; Douglas A. Chapnick; Xuedong Liu

doi:10.1074/jbc.m117.783175

Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response

Journal of Biological Chemistry ◽

10.1074/jbc.m117.783175 ◽

2017 ◽

Vol 292 (36) ◽

pp. 15105-15120 ◽

Cited By ~ 21

Author(s):

Conggang Zhang ◽

Zeyu Liu ◽

Eric Bunker ◽

Adrian Ramirez ◽

Schuyler Lee ◽

...

Keyword(s):

Electron Transport ◽

Atp Synthase ◽

Electron Transport Chain ◽

Drug Response ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Chromium(V) is produced upon reduction of chromate by mitochondrial electron transport chain complexes

Carcinogenesis ◽

10.1093/carcin/10.5.913 ◽

1989 ◽

Vol 10 (5) ◽

pp. 913-920 ◽

Cited By ~ 26

Author(s):

S. C. Rossi ◽

K. E. Wetterhahn

Keyword(s):

Electron Transport ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

PLoS ONE ◽

10.1371/journal.pone.0020151 ◽

2011 ◽

Vol 6 (5) ◽

pp. e20151 ◽

Cited By ~ 111

Author(s):

Kartick C. Pramanik ◽

Srinivas Reddy Boreddy ◽

Sanjay K. Srivastava

Keyword(s):

Oxidative Stress ◽

Pancreatic Cancer ◽

Electron Transport ◽

Cancer Cells ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Pancreatic Cancer Cells ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Roles of different mitochondrial electron transport chain complexes in hypoxia-induced pulmonary vasoconstriction

Cell Biology International ◽

10.1002/cbin.10550 ◽

2015 ◽

Vol 40 (2) ◽

pp. 188-195 ◽

Cited By ~ 3

Author(s):

Zhao Yang ◽

Bing Zhuan ◽

Ying Yan ◽

Simin Jiang ◽

Tao Wang

Keyword(s):

Electron Transport ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Pulmonary Vasoconstriction ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: role of l-carnitine

Chemico-Biological Interactions ◽

10.1016/j.cbi.2003.10.010 ◽

2004 ◽

Vol 148 (1-2) ◽

pp. 11-18 ◽

Cited By ~ 40

Author(s):

Sundaram Kumaran ◽

Marimuthu Subathra ◽

Muthiyah Balu ◽

Chinnakkannu Panneerselvam

Keyword(s):

Skeletal Muscle ◽

Electron Transport ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes

PLoS ONE ◽

10.1371/journal.pone.0143600 ◽

2015 ◽

Vol 10 (12) ◽

pp. e0143600 ◽

Cited By ~ 17

Author(s):

Yung-Ting Kuo ◽

Ping-Hsiao Shih ◽

Shu-Huei Kao ◽

Geng-Chang Yeh ◽

Horng-Mo Lee

Keyword(s):

Skeletal Muscle ◽

Electron Transport ◽

Muscle Atrophy ◽

Electron Transport Chain ◽

Pyrroloquinoline Quinone ◽

Skeletal Muscle Atrophy ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2011.07189.x ◽

2011 ◽

Vol 117 (2) ◽

pp. 209-220 ◽

Cited By ~ 102

Author(s):

Abha Chauhan ◽

Feng Gu ◽

Musthafa M. Essa ◽

Jerzy Wegiel ◽

Kulbir Kaur ◽

...

Keyword(s):

Electron Transport ◽

Brain Region ◽

Electron Transport Chain ◽

Children With Autism ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Deletion of Von Willebrand A Domain Containing Protein (VWA8) raises activity of mitochondrial electron transport chain complexes in hepatocytes

Biochemistry and Biophysics Reports ◽

10.1016/j.bbrep.2021.100928 ◽

2021 ◽

Vol 26 ◽

pp. 100928

Author(s):

Moulun Luo ◽

Wuqiong Ma ◽

Rocio Zapata-Bustos ◽

Wayne T. Willis ◽

Lawrence J. Mandarino

Keyword(s):

Electron Transport ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain ◽

Von Willebrand

Download Full-text

Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2008.06.006 ◽

2008 ◽

Vol 45 (6) ◽

pp. 826-838 ◽

Cited By ~ 44

Author(s):

Kashyap B. Choksi ◽

Jonathan E. Nuss ◽

James H. DeFord ◽

John Papaconstantinou

Keyword(s):

Skeletal Muscle ◽

Electron Transport ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Mouse Skeletal Muscle ◽

Age Related ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Age-related alterations in oxidatively damaged proteins of mouse heart mitochondrial electron transport chain complexes

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2008.01.032 ◽

2008 ◽

Vol 44 (10) ◽

pp. 1795-1805 ◽

Cited By ~ 48

Author(s):

Kashyap B. Choksi ◽

John Papaconstantinou

Keyword(s):

Electron Transport ◽

Electron Transport Chain ◽

Mouse Heart ◽

Mitochondrial Electron Transport Chain ◽

Age Related ◽

Chain Complexes ◽

Transport Chain

Download Full-text

Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

Current Pharmaceutical Biotechnology ◽

10.2174/1389201011314030011 ◽

2013 ◽

Vol 14 (3) ◽

pp. 377-389 ◽

Cited By ~ 19

Author(s):

Jakub Rohlena ◽

Lan-feng Dong ◽

Jiri Neuzil

Keyword(s):

Electron Transport ◽

Cancer Treatment ◽

Electron Transport Chain ◽

Mitochondrial Electron Transport Chain ◽

Chain Complexes ◽

Transport Chain ◽

Induction Of Apoptosis

Download Full-text