scholarly journals Endoplasmic reticulum oxidase 1α is critical for collagen secretion from and membrane type 1-matrix metalloproteinase levels in hepatic stellate cells

2017 ◽  
Vol 292 (38) ◽  
pp. 15649-15660 ◽  
Author(s):  
Mizuki Fujii ◽  
Akihiro Yoneda ◽  
Norio Takei ◽  
Kaori Sakai-Sawada ◽  
Marina Kosaka ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Matrix Metalloproteinase ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Collagen Secretion ◽  
Membrane Type

scholarly journals Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

2014 ◽  
Vol 289 (29) ◽  
pp. 20209-20221 ◽  
Author(s):  
Naoko Kubo Birukawa ◽  
Kazuyuki Murase ◽  
Yasushi Sato ◽  
Akemi Kosaka ◽  
Akihiro Yoneda ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Activated Hepatic Stellate Cells ◽  
Membrane Type

Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis

2000 ◽  
Vol 279 (2) ◽  
pp. G245-G249 ◽  
Author(s):  
Michael J. P. Arthur
Keyword(s):  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Matrix Proteins ◽  
Gelatinase A ◽  
Fibrotic Liver ◽  
Fibrillar Collagens ◽  
Membrane Type ◽  
Interstitial Collagenase

Liver fibrosis is characterized by activation of hepatic stellate cells, which are then involved in synthesis of matrix proteins and in regulating matrix degradation. In the acute phases of liver injury and as liver fibrosis progresses, there is increased expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Among the changes described, striking features include increased expression of gelatinase A (MMP-2) and membrane type 1-MMP (MT1-MMP; MMP-14) as well as TIMP-1 and TIMP-2. These molecules and other family members are involved in regulating degradation of both normal and fibrotic liver matrix. This article outlines recent progress in this field and discusses the mechanisms by which MMPs and TIMPs may contribute to the progression and regression of liver fibrosis. Recently described properties of MMPs and TIMPs of relevance to the pathogenesis of liver fibrosis are outlined. The proposal that regression of liver fibrosis is mediated by decreased expression of TIMPs and involves degradation of fibrillar collagens by a combination of MT1-MMP and gelatinase A, in addition to interstitial collagenase, is explored.

scholarly journals Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing

2005 ◽  
Vol 280 (28) ◽  
pp. 26160-26168 ◽  
Author(s):  
Pamela Osenkowski ◽  
Samy O. Meroueh ◽  
Dumitru Pavel ◽  
Shahriar Mobashery ◽  
Rafael Fridman
Keyword(s):  
Matrix Metalloproteinase ◽  
Hinge Region ◽  
Membrane Type
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