scholarly journals The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter

2016 ◽  
Vol 291 (9) ◽  
pp. 4453-4461 ◽  
Author(s):  
Maria E. Zoghbi ◽  
Rebecca S. Cooper ◽  
Guillermo A. Altenberg
Keyword(s):  
Lipid Bilayer ◽  
Structure And Function ◽  
Atp Binding ◽  
And Function ◽  
Atp Binding Cassette

scholarly journals Detergent-free purification of ABC (ATP-binding-cassette) transporters

2014 ◽  
Vol 461 (2) ◽  
pp. 269-278 ◽  
Author(s):  
Sonali Gulati ◽  
Mohammed Jamshad ◽  
Timothy J. Knowles ◽  
Kerrie A. Morrison ◽  
Rebecca Downing ◽  
...  
Keyword(s):  
Maleic Acid ◽  
Transmembrane Proteins ◽  
Structure And Function ◽  
Atp Binding ◽  
Acid Copolymer ◽  
Atp Binding Cassette Transporters ◽  
And Function ◽  
Maleic Acid Copolymer ◽  
Atp Binding Cassette

A styrene maleic acid copolymer can be effectively used to extract and purify large eukaryotic transmembrane proteins in the absence of detergents, forming small bilayer discs encapsulating the protein, which have great potential for future structure and function studies.

scholarly journals Role of the ATP-Binding Cassette TransporterAbcg2in the Phenotype and Function of Cardiac Side Population Cells

2008 ◽  
Vol 103 (8) ◽  
pp. 825-835 ◽  
Author(s):  
Otmar Pfister ◽  
Angelos Oikonomopoulos ◽  
Konstantina-Ioanna Sereti ◽  
Regina L. Sohn ◽  
Darragh Cullen ◽  
...  
Keyword(s):  
Side Population ◽  
Atp Binding ◽  
Side Population Cells ◽  
And Function ◽  
Atp Binding Cassette

scholarly journals Evolutionary Analyses of ABC Transporters of Dictyostelium discoideum

2002 ◽  
Vol 1 (4) ◽  
pp. 643-652 ◽  
Author(s):  
Christophe Anjard ◽  
William F. Loomis
Keyword(s):  
Amino Acid ◽  
Dictyostelium Discoideum ◽  
Abc Transporters ◽  
Sequence Homology ◽  
Genome Project ◽  
The Other ◽  
Atp Binding ◽  
And Function ◽  
Insight Into ◽  
Atp Binding Cassette

ABSTRACT The ABC superfamily of genes is one of the largest in the genomes of both bacteria and eukaryotes. The proteins encoded by these genes all carry a characteristic 200- to 250-amino-acid ATP-binding cassette that gives them their family name. In bacteria they are mostly involved in nutrient import, while in eukaryotes many are involved in export. Seven different families have been defined in eukaryotes based on sequence homology, domain topology, and function. While only 6 ABC genes in Dictyostelium discoideum have been studied in detail previously, sequences from the well-advanced Dictyostelium genome project have allowed us to recognize 68 members of this superfamily. They have been classified and compared to animal, plant, and fungal orthologs in order to gain some insight into the evolution of this superfamily. It appears that many of the genes inferred to have been present in the ancestor of the crown organisms duplicated extensively in some but not all phyla, while others were lost in one lineage or the other.

scholarly journals Structure and function of membrane proteins encapsulated in a polymer-bound lipid bilayer

2018 ◽  
Vol 1860 (4) ◽  
pp. 809-817 ◽  
Author(s):  
Naomi L. Pollock ◽  
Sarah C. Lee ◽  
Jaimin H. Patel ◽  
Aiman A. Gulamhussein ◽  
Alice J. Rothnie
Keyword(s):  
Membrane Proteins ◽  
Lipid Bilayer ◽  
Structure And Function ◽  
And Function

Localization and function of ATP-binding cassette C (ABCC/MRP) efflux pumps in human brain

2007 ◽  
pp. 112-123
Author(s):  
A. T. Nies ◽  
M. Rius ◽  
J. König ◽  
C. Herold-Mende ◽  
D. Keppler
Keyword(s):  
Human Brain ◽  
Efflux Pumps ◽  
Atp Binding ◽  
And Function ◽  
Atp Binding Cassette

scholarly journals The power, pitfalls and potential of the nanodisc system for NMR-based studies

2016 ◽  
Vol 397 (12) ◽  
pp. 1335-1354 ◽  
Author(s):  
Aldino Viegas ◽  
Thibault Viennet ◽  
Manuel Etzkorn
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Membrane Proteins ◽  
Lipid Bilayer ◽  
Structure And Function ◽  
Fundamental Importance ◽  
Future Studies ◽  
And Function ◽  
Unique Potential

Abstract The choice of a suitable membrane mimicking environment is of fundamental importance for the characterization of structure and function of membrane proteins. In this respect, usage of the lipid bilayer nanodisc technology provides a unique potential for nuclear magnetic resonance (NMR)-based studies. This review summarizes the recent advances in this field, focusing on (i) the strengths of the system, (ii) the bottlenecks that may be faced, and (iii) promising capabilities that may be explored in future studies.

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