scholarly journals Tumor Necrosis Factor and Transforming Growth Factor β Regulate Clock Genes by Controlling the Expression of the Cold Inducible RNA-binding Protein (CIRBP)

2013 ◽  
Vol 289 (5) ◽  
pp. 2736-2744 ◽  
Author(s):  
Martin Lopez ◽  
Daniel Meier ◽  
Andreas Müller ◽  
Paul Franken ◽  
Jun Fujita ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Rna Binding ◽  
Transforming Growth Factor ◽  
Clock Genes ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Transforming Growth Factor Β ◽  
Necrosis Factor

scholarly journals Inhibition of Mycobacterium bovisBCG-Induced Tumor Necrosis Factor Alpha Secretion in Human Cells by Transforming Growth Factor β

1998 ◽  
Vol 5 (4) ◽  
pp. 588-591 ◽  
Author(s):  
Patricia Méndez-Samperio ◽  
Marisol Hernandez-Garay ◽  
Angela Nuñez Vazquez
Keyword(s):  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Cells ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT The effect of exogenous transforming growth factor β (TGF-β) onMycobacterium bovis BCG-induced tumor necrosis factor alpha (TNF-α) production by human mononuclear cells was studied. It was found that TNF-α production by human cells stimulated with BCG was significantly inhibited by TGF-β. The specificity of the observed inhibition was demonstrated, since the addition of an anti-TGF-β neutralizing monoclonal antibody completely reversed the inhibitory effect. Furthermore, the suppressive effect of TGF-β on TNF-α secretion in this system was not due to a direct cytotoxic effect, since cell viability was comparable in the presence or absence of TGF-β. Interestingly, our results demonstrated comparative suppressive effects of TGF-β and interleukin-10 on BCG-induced TNF-α secretion. Together, the data demonstrate, for the first time, that TGF-β inhibits BCG-induced TNF-α secretion by human cells.

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