scholarly journals Cell Cycle-dependent Subcellular Translocation of the Human DNA Licensing Inhibitor Geminin

2013 ◽  
Vol 288 (33) ◽  
pp. 23953-23963 ◽  
Author(s):  
Maria Dimaki ◽  
Georgia Xouri ◽  
Ioanna-Eleni Symeonidou ◽  
Chaido Sirinian ◽  
Hideo Nishitani ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Human Dna ◽  
Subcellular Translocation ◽  
Dna Licensing ◽  
Cycle Dependent

scholarly journals Cell Cycle-dependent Phosphorylation of Human DNA Ligase I at the Cyclin-dependent Kinase Sites

2003 ◽  
Vol 278 (39) ◽  
pp. 37761-37767 ◽  
Author(s):  
Giovanni Ferrari ◽  
Rossella Rossi ◽  
Daniele Arosio ◽  
Alessandro Vindigni ◽  
Giuseppe Biamonti ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Ligase ◽  
Cyclin Dependent Kinase ◽  
Human Dna ◽  
Dna Ligase I ◽  
Cycle Dependent

scholarly journals Cell Cycle-dependent Regulation of a Human DNA Helicase That Localizes in DNA Damage Foci

2004 ◽  
Vol 15 (7) ◽  
pp. 3320-3332 ◽  
Author(s):  
Jinming Gu ◽  
Xiaobo Xia ◽  
Peijun Yan ◽  
Hanjian Liu ◽  
Vladimir N. Podust ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Nuclear Export ◽  
Mutational Analysis ◽  
Dna Helicase ◽  
Reporter Protein ◽  
Human Dna ◽  
Focal Pattern ◽  
Cycle Dependent

Mutational studies of human DNA helicase B (HDHB) have suggested that its activity is critical for the G1/S transition of the cell cycle, but the nature of its role remains unknown. In this study, we show that during G1, ectopically expressed HDHB localizes in nuclear foci induced by DNA damaging agents and that this focal pattern requires active HDHB. During S and G2/M, HDHB localizes primarily in the cytoplasm. A carboxy-terminal domain from HDHB confers cell cycle-dependent localization, but not the focal pattern, to a reporter protein. A cluster of potential cyclin-dependent kinase phosphorylation sites in this domain was modified at the G1/S transition and maintained through G2/M of the cell cycle in vivo, coincident with nuclear export of HDHB. Serine 967 of HDHB was the major site phosphorylated in vivo and in vitro by cyclin-dependent kinases. Mutational analysis demonstrated that phosphorylation of serine 967 is crucial in regulating the subcellular localization of ectopically expressed HDHB. We propose that the helicase of HDHB operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2.

scholarly journals Cell cycle-dependent phosphorylation of human DNA polymerase alpha.

1991 ◽  
Vol 266 (12) ◽  
pp. 7893-7903
Author(s):  
H P Nasheuer ◽  
A Moore ◽  
A F Wahl ◽  
T S Wang
Keyword(s):  
Cell Cycle ◽  
Dna Polymerase ◽  
Dna Polymerase Alpha ◽  
Human Dna ◽  
Cycle Dependent

Cell cycle dependent modulation of insulin and IGF I receptor binding to human Burkitt type ALL cells

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S81
Author(s):  
U. VETTER ◽  
W. HARTMANN ◽  
H. HITZLER ◽  
W. HEIT ◽  
J. SCHLICKENRIEDER ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Receptor Binding ◽  
Igf I ◽  
Cycle Dependent
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