scholarly journals The Dual-specificity Phosphatase DUSP14 Negatively Regulates Tumor Necrosis Factor- and Interleukin-1-induced Nuclear Factor-κB Activation by Dephosphorylating the Protein Kinase TAK1

2012 ◽  
Vol 288 (2) ◽  
pp. 819-825 ◽  
Author(s):  
Hao Zheng ◽  
Qi Li ◽  
Rui Chen ◽  
Jing Zhang ◽  
Yong Ran ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Necrosis Factor

scholarly journals The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 ◽  
Vol 187 (12) ◽  
pp. 2097-2101 ◽  
Author(s):  
Marta Muzio ◽  
Gioacchino Natoli ◽  
Simona Saccani ◽  
Massimo Levrero ◽  
Alberto Mantovani
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Tumor Necrosis Factor Receptor ◽  
Nuclear Factor Κb ◽  
Dominant Negative ◽  
Nuclear Factor ◽  
Kinase C ◽  
Toll Signaling ◽  
Necrosis Factor

The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity. Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R–associated kinase. Tumor necrosis factor receptor–activated factor 6 (TRAF6) and the nuclear factor κB (NF-κB)–inducing kinase (NIK) are both involved in subsequent steps of NF-κB activation. Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.

Protein Kinase Cδ Activates RelA/p65 and Nuclear Factor-κB Signaling in Response to Tumor Necrosis Factor-α

2009 ◽  
Vol 69 (14) ◽  
pp. 5927-5935 ◽  
Author(s):  
Zheng-Guang Lu ◽  
Hanshao Liu ◽  
Tomoko Yamaguchi ◽  
Yoshio Miki ◽  
Kiyotsugu Yoshida
Keyword(s):  
Protein Kinase ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Factor Α ◽  
Necrosis Factor ◽  
Protein Kinase Cδ
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