scholarly journals Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

2012 ◽  
Vol 287 (44) ◽  
pp. 37245-37258 ◽  
Author(s):  
Jordan T. Newington ◽  
Tim Rappon ◽  
Shawn Albers ◽  
Daisy Y. Wong ◽  
R. Jane Rylett ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lactate Dehydrogenase ◽  
Pyruvate Dehydrogenase ◽  
Mitochondrial Respiration ◽  
Reactive Oxygen Species Production ◽  
Amyloid Β ◽  
Pyruvate Dehydrogenase Kinase ◽  
Oxygen Species ◽  
Pyruvate Dehydrogenase Kinase 1 ◽  
Species Production

scholarly journals Regulation of mitochondria function by natriuretic peptides

2019 ◽  
Vol 317 (5) ◽  
pp. F1164-F1168
Author(s):  
Mark Domondon ◽  
Anna B. Nikiforova ◽  
Kristine Y. DeLeon-Pennell ◽  
Daria V. Ilatovskaya
Keyword(s):  
Blood Pressure ◽  
Reactive Oxygen Species ◽  
Natriuretic Peptides ◽  
Mitochondrial Respiration ◽  
Reactive Oxygen Species Production ◽  
Current Knowledge ◽  
Fluid Retention ◽  
Oxygen Species ◽  
Species Production ◽  
The Relationship

Natriuretic peptides (NPs) are well known to promote renal Na+ excretion, counteracting the effects of the renin-angiotensin-aldosterone system. Thus, NPs serve as a key component in the maintenance of blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis and enhance lipid oxidation and mitochondrial respiration. Here, we provide an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, Ca2+ signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed at understanding and potentially using it as a therapeutic target from a completely new angle.

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