scholarly journals Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

2012 ◽  
Vol 287 (31) ◽  
pp. 26060-26067 ◽  
Author(s):  
Shufang Wu ◽  
Amy Levenson ◽  
Alexei Kharitonenkov ◽  
Francesco De Luca
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Plate ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Hormone Action ◽  
Growth Hormone Action

Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans

2013 ◽  
Vol 274 (3) ◽  
pp. 227-232 ◽  
Author(s):  
J. Lundberg ◽  
C. Höybye ◽  
T. Krusenstjerna-Hafstrøm ◽  
H. A. Bina ◽  
A. Kharitonenkov ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

scholarly journals Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

2011 ◽  
Vol 286 (40) ◽  
pp. 34559-34566 ◽  
Author(s):  
Wei Chen ◽  
Ruby Lai-chong Hoo ◽  
Morichika Konishi ◽  
Nobuyuki Itoh ◽  
Pui-chi Lee ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

scholarly journals Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation

2017 ◽  
Vol 37 ◽  
pp. 1-6 ◽  
Author(s):  
Laurie R. Braun ◽  
Meghan N. Feldpausch ◽  
Natalia Czerwonka ◽  
Martin Torriani ◽  
Steven K. Grinspoon ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Liver Fat ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Fat Reduction

scholarly journals Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Ravneet K. Boparai ◽  
Oge Arum ◽  
Johanna G. Miquet ◽  
Michal M. Masternak ◽  
Andrzej Bartke ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Lipid Metabolism ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Fibroblast Growth Factor ◽  
Energy Homeostasis ◽  
Antioxidant Defense ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Beneficial Effects

Fibroblast growth factor 21 (FGF21) modulates a diverse range of biological functions, including glucose and lipid metabolism, adaptive starvation response, and energy homeostasis, but with limited mechanistic insight. FGF21 treatment has been shown to inhibit hepatic growth hormone (GH) intracellular signaling. To evaluate GH axis involvement in FGF21 actions, transgenic mice overexpressing bovine GH were used. Expectedly, in response to FGF21 treatment control littermates showed metabolic improvements whereas GH transgenic mice resisted most of the beneficial effects of FGF21, except an attenuation of the innate hyperinsulinemia. Since FGF21 is believed to exert its effects mostly at the transcriptional level, we analyzed and observed significant upregulation in expression of various genes involved in carbohydrate and lipid metabolism, energy homeostasis, and antioxidant defense in FGF21-treated controls, but not in GH transgenics. The resistance of GH transgenic mice to FGF21-induced changes underlines the necessity of normal GH signaling for the beneficial effects of FGF21.

Sign in / Sign up

Export Citation Format

Share Document