Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a

Naomasa Kakiya; Takashi Saito; Per Nilsson; Yukio Matsuba; Satoshi Tsubuki; Nobuyuki Takei; Hiroyuki Nawa; Takaomi C. Saido

doi:10.1074/jbc.m112.340372

Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a

Journal of Biological Chemistry ◽

10.1074/jbc.m112.340372 ◽

2012 ◽

Vol 287 (35) ◽

pp. 29362-29372 ◽

Cited By ~ 25

Author(s):

Naomasa Kakiya ◽

Takashi Saito ◽

Per Nilsson ◽

Yukio Matsuba ◽

Satoshi Tsubuki ◽

...

Keyword(s):

Protein Kinase ◽

Protein Phosphatase ◽

Amyloid Β ◽

Surface Expression ◽

Mitogen Activated Protein Kinase ◽

Cell Surface Expression ◽

Amyloid Β Peptide ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein

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Faculty Opinions recommendation of Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006218.77810 ◽

2002 ◽

Author(s):

Angel Nebreda

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Premature Senescence ◽

Extracellular Signal Regulated Kinase ◽

Oncogenic Ras ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Sequential Activation

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Big Mitogen-Activated Protein Kinase 1 (BMK1)/Extracellular Signal Regulated Kinase 5 (ERK5) Is Involved in Platelet-Derived Growth Factor (PDGF)-Induced Vascular Smooth Muscle Cell Migration

Hypertension Research ◽

10.1291/hypres.30.1107 ◽

2007 ◽

Vol 30 (11) ◽

pp. 1107-1117 ◽

Cited By ~ 23

Author(s):

Yuki IZAWA ◽

Masanori YOSHIZUMI ◽

Keisuke ISHIZAWA ◽

Yoshiko FUJITA ◽

Shuji KONDO ◽

...

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Platelet Derived Growth Factor ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Smooth Muscle Cell Migration ◽

Mitogen Activated Protein

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Cooperation of p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways during Granulocyte Colony-stimulating Factor-induced Hemopoietic Cell Proliferation

Journal of Biological Chemistry ◽

10.1074/jbc.274.7.4096 ◽

1999 ◽

Vol 274 (7) ◽

pp. 4096-4105 ◽

Cited By ~ 80

Author(s):

Oliver Rausch ◽

Christopher J. Marshall

Keyword(s):

Cell Proliferation ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Hemopoietic Cell ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Stimulating Factor

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Plasma leptin concentrations are greater in type II diabetic patients and stimulate monocyte chemotactic peptide-1 synthesis via the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

Kidney Research and Clinical Practice ◽

10.1016/j.krcp.2012.06.004 ◽

2012 ◽

Vol 31 (3) ◽

pp. 177-185 ◽

Cited By ~ 3

Author(s):

Jin Joo Cha ◽

Young Youl Hyun ◽

Yi Hwa Jee ◽

Mi Jin Lee ◽

Kum Hyun Han ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Diabetic Patients ◽

Type Ii ◽

Chemotactic Peptide ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Plasma Leptin ◽

Kinase Pathway

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MEK5/ERK5: Mitogen-Activated Protein Kinase 5/Extracellular Signal-Regulated Kinase 5

Encyclopedia of Signaling Molecules ◽

10.1007/978-1-4419-0461-4_100786 ◽

2012 ◽

pp. 1074-1074

Author(s):

Andreas Gewies ◽

Jürgen Ruland ◽

Alexey Kotlyarov ◽

Matthias Gaestel ◽

Shiri Procaccia ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein

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The Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Activates the Extracellular Signal–Regulated Kinase Mitogen-Activated Protein Kinase Pathway

Cancer Research ◽

10.1158/0008-5472.can-07-2821 ◽

2007 ◽

Vol 67 (23) ◽

pp. 11455-11462 ◽

Cited By ~ 20

Author(s):

Stuart K. Creton ◽

Huijun Zhu ◽

Nigel J. Gooderham

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Cooked Meat ◽

Kinase Pathway

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CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK)

European Journal of Biochemistry ◽

10.1046/j.0014-2956.2001.02553.x ◽

2001 ◽

Vol 268 (23) ◽

pp. 6058-6065 ◽

Cited By ~ 101

Author(s):

Gen Yosimichi ◽

Tohru Nakanishi ◽

Takashi Nishida ◽

Takako Hattori ◽

Teruko Takano-Yamamoto ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Chondrocyte Differentiation ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein

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Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal–regulated kinase, and phosphorylated AKT in colorectal cancer—A tissue microarray–based approach☆

Human Pathology ◽

10.1016/j.humpath.2006.03.002 ◽

2006 ◽

Vol 37 (8) ◽

pp. 1022-1031 ◽

Cited By ~ 33

Author(s):

A LUGLI ◽

I ZLOBEC ◽

P MINOO ◽

K BAKER ◽

L TORNILLO ◽

...

Keyword(s):

Colorectal Cancer ◽

Protein Kinase ◽

Tissue Microarray ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Phosphorylated Akt ◽

Mitogen Activated Protein ◽

Phosphoinositide 3 Kinase

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Glycogen Synthase Kinase 3β Is a Natural Activator of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Kinase 1 (MEKK1)

Journal of Biological Chemistry ◽

10.1074/jbc.m300253200 ◽

2003 ◽

Vol 278 (16) ◽

pp. 13995-14001 ◽

Cited By ~ 55

Author(s):

Jin Woo Kim ◽

Ji Eun Lee ◽

Myung Jin Kim ◽

Eun-Gyung Cho ◽

Ssang-Goo Cho ◽

...

Keyword(s):

Protein Kinase ◽

Glycogen Synthase ◽

Mitogen Activated Protein Kinase ◽

Glycogen Synthase Kinase ◽

Glycogen Synthase Kinase 3Β ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein

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Inhibition of p38 mitogen activated protein kinase increases lipopolysaccharide induced inhibition of apoptosis in neutrophils by activating extracellular signal-regulated kinase

Surgery ◽

10.1067/msy.2001.115902 ◽

2001 ◽

Vol 130 (2) ◽

pp. 242-248 ◽

Cited By ~ 43

Author(s):

Ketan Sheth ◽

John Friel ◽

Brian Nolan ◽

Paul Bankey

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein

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