scholarly journals Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway

2012 ◽  
Vol 287 (21) ◽  
pp. 17224-17231 ◽  
Author(s):  
Ahmed M. Hamdan ◽  
Satoru Koyanagi ◽  
Erika Wada ◽  
Naoki Kusunose ◽  
Yuichi Murakami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Circadian Clock ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Activating Transcription Factor 4 ◽  
Resistance Protein ◽  
Activating Transcription Factor ◽  
Transcription Factor 4

scholarly journals Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling

2018 ◽  
Vol 24 (22) ◽  
pp. 5697-5709 ◽  
Author(s):  
Adrián González-González ◽  
Esperanza Muñoz-Muela ◽  
Juan A. Marchal ◽  
Francisca E. Cara ◽  
Maria P. Molina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Activating Transcription Factor 4 ◽  
Activating Transcription Factor ◽  
Transcription Factor 4

scholarly journals Activating Transcription Factor 4 Promotes Angiogenesis of Breast Cancer through Enhanced Macrophage Recruitment

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Liu ◽  
Zongjin Li ◽  
Lina Wang ◽  
Lingling Tong ◽  
Ningning He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Tumor Angiogenesis ◽  
Breast Cancer Cells ◽  
Activating Transcription Factor 4 ◽  
Tumor Tissues ◽  
Activating Transcription Factor ◽  
Transcription Factor 4

Angiogenesis plays an important role in the progression of tumor. Besides being regulated by tumor cells per se, tumor angiogenesis is also influenced by stromal cells in tumor microenvironment (TME), for example, tumor associated macrophages (TAMs). Activating transcription factor 4 (ATF4), a member of the ATF/CREB family, has been reported to be related to tumor angiogenesis. In this study, we found that exogenous overexpression of ATF4 in mouse breast cancer cells promotes tumor growth via increasing tumor microvascular density. However, ATF4 overexpression failed to increase the expression level of a series of proangiogenic factors including vascular endothelial growth factor A (VEGFA) in tumor cells in this model. Thus, we further investigated the infiltration of proangiogenic macrophages in tumor tissues and found that ATF4-overexpressing tumors could recruit more macrophages via secretion of macrophage colony stimulating factor (M-CSF). Overall, we concluded that exogenous overexpression of ATF4 in breast cancer cells may facilitate the recruitment of macrophages into tumor tissues and promote tumor angiogenesis and tumor growth indirectly.

Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Sonali Mehendale-Munj
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Protein A ◽  
The Body ◽  
Cancer Therapies ◽  
Cancer Resistance ◽  
Lung Cancers ◽  
Resistance Protein ◽  
Atp Regulation ◽  
Treatment Procedures

: Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug re-sistance(MDR). It is known to expel many potent antineoplastic drugs, owing to its efflux function. Efflux of chemothera-peutics because of BCRP develops resistance to manydrugs, leading to failure in cancer treatment. BCRP plays an important role in physiology by protecting the organism from xenobiotics and other toxins. It is a half-transporter affiliated to theATP-binding cassette (ABC) superfamily of transporters, encoded by the gene ABCG2 and functions in response to adenosine triphosphate (ATP). Regulation of BCRP expression is critically controlled at molecular levels which help in maintaining the balance of xenobiotics and nutrients inside the body. Expression of BCRP can be found in brain, liver, lung cancers and acute myeloid leukemia (AML). Moreover, it is also expressed at high levels in stem cells and many cell lines. This frequent expression of BCRP has an impact on the treatment procedures and if not scrutinized may lead to failure of many cancer therapies.

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