scholarly journals The Human Biliverdin Reductase-based Peptide Fragments and Biliverdin Regulate Protein Kinase Cδ Activity

2012 ◽  
Vol 287 (29) ◽  
pp. 24698-24712 ◽  
Author(s):  
Tihomir Miralem ◽  
Nicole Lerner-Marmarosh ◽  
Peter E. M. Gibbs ◽  
Cicerone Tudor ◽  
Fred K. Hagen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Peptide Fragments ◽  
Biliverdin Reductase ◽  
Regulate Protein ◽  
Protein Kinase Cδ

scholarly journals Androgens Regulate Protein Kinase Cδ Transcription and Modulate Its Apoptotic Function in Prostate Cancer Cells

2006 ◽  
Vol 66 (24) ◽  
pp. 11792-11801 ◽  
Author(s):  
M. Veronica Gavrielides ◽  
Anatilde M. Gonzalez-Guerrico ◽  
Natalia A. Riobo ◽  
Marcelo G. Kazanietz
Keyword(s):  
Prostate Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Regulate Protein ◽  
Protein Kinase Cδ

scholarly journals The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

2012 ◽  
Vol 64 (6) ◽  
pp. 1950-1959 ◽  
Author(s):  
Michael B. Ellman ◽  
Jae-Sung Kim ◽  
Howard S. An ◽  
Jeffrey S. Kroin ◽  
Xin Li ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Ex Vivo ◽  
Intervertebral Discs ◽  
In Vivo Studies ◽  
Protein Kinase Cδ

scholarly journals Down-Regulation of Protein Kinase Cδ Inhibits Inducible Nitric Oxide Synthase Expression through IRF1

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e52741 ◽  
Author(s):  
Tiina Leppänen ◽  
Riku Korhonen ◽  
Mirka Laavola ◽  
Riina Nieminen ◽  
Raimo K. Tuominen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Down Regulation ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Protein Kinase Cδ

scholarly journals miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase Cδ

Endocrinology ◽  
2013 ◽  
Vol 154 (5) ◽  
pp. 1690-1700 ◽  
Author(s):  
Erica Gentilin ◽  
Federico Tagliati ◽  
Carlo Filieri ◽  
Daniela Molè ◽  
Mariella Minoia ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pituitary Adenoma ◽  
Protein Kinase ◽  
Pituitary Adenomas ◽  
Viable Cell Number ◽  
Pituitary Cells ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Acth Secreting ◽  
Protein Kinase Cδ

Abstract The functional aftermath of microRNA (miRNA) dysregulation in ACTH-secreting pituitary adenomas has not been demonstrated. miRNAs represent diagnostic and prognostic biomarkers as well as putative therapeutic targets; their investigation may shed light on the mechanisms that underpin pituitary adenoma development and progression. Drugs interacting with such pathways may help in achieving disease control also in the settings of ACTH-secreting pituitary adenomas. We investigated the expression of 10 miRNAs among those that were found as most dysregulated in human pituitary adenoma tissues in the settings of a murine ACTH-secreting pituitary adenoma cell line, AtT20/D16v-F2. The selected miRNAs to be submitted to further investigation in AtT20/D16v-F2 cells represent an expression panel including 5 up-regulated and 5 down-regulated miRNAs. Among these, we selected the most dysregulated mouse miRNA and searched for miRNA targets and their biological function. We found that AtT20/D16v-F2 cells have a specific miRNA expression profile and that miR-26a is the most dysregulated miRNA. The latter is overexpressed in human pituitary adenomas and can control viable cell number in the in vitro model without involving caspase 3/7-mediated apoptosis. We demonstrated that protein kinase Cδ (PRKCD) is a direct target of miR-26a and that miR26a inhibition delays the cell cycle in G1 phase. This effect involves down-regulation of cyclin E and cyclin A expression via PRKCD modulation. miR-26a and related pathways, such as PRKCD, play an important role in cell cycle control of ACTH pituitary cells, opening new therapeutic possibilities for the treatment of persistent/recurrent Cushing's disease.

scholarly journals Protein kinase Cδ expression in breast cancer as measured by real-time PCR, western blotting and ELISA

2008 ◽  
Vol 99 (10) ◽  
pp. 1644-1650 ◽  
Author(s):  
E McKiernan ◽  
K O'Brien ◽  
N Grebenchtchikov ◽  
A Geurts-Moespot ◽  
A M Sieuwerts ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Kinase ◽  
Real Time ◽  
Western Blotting ◽  
Real Time Pcr ◽  
Protein Kinase Cδ
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