scholarly journals Metastasis-associated Protein 1 Drives Tumor Cell Migration and Invasion through Transcriptional Repression of RING Finger Protein 144A

2011 ◽  
Vol 287 (8) ◽  
pp. 5615-5626 ◽  
Author(s):  
Hezlin Marzook ◽  
Da-Qiang Li ◽  
Vasudha S. Nair ◽  
Prakriti Mudvari ◽  
Sirigiri Divijendra Natha Reddy ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Transcriptional Repression ◽  
Ring Finger ◽  
Migration And Invasion ◽  
Ring Finger Protein ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Finger Protein

scholarly journals Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A.: FIGURE 3.

2012 ◽  
Vol 287 (15) ◽  
pp. 12158-12158
Author(s):  
Hezlin Marzook ◽  
Da-Qiang Li ◽  
Vasudha S. Nair ◽  
Prakriti Mudvari ◽  
Sirigiri Divijendra Natha Reddy ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Transcriptional Repression ◽  
Ring Finger ◽  
Migration And Invasion ◽  
Ring Finger Protein ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Finger Protein

scholarly journals Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A.

2015 ◽  
Vol 290 (11) ◽  
pp. 6751-6751 ◽  
Author(s):  
Hezlin Marzook ◽  
Da-Qiang Li ◽  
Vasudha S. Nair ◽  
Prakriti Mudvari ◽  
Sirigiri Divijendra Natha Reddy ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Transcriptional Repression ◽  
Ring Finger ◽  
Migration And Invasion ◽  
Ring Finger Protein ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Finger Protein

scholarly journals Id2 Promotes Tumor Cell Migration and Invasion through Transcriptional Repression of Semaphorin 3F

2010 ◽  
Vol 70 (9) ◽  
pp. 3823-3832 ◽  
Author(s):  
Silvia Coma ◽  
Dhara N. Amin ◽  
Akio Shimizu ◽  
Anna Lasorella ◽  
Antonio Iavarone ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Transcriptional Repression ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Semaphorin 3F

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

2008 ◽  
Vol 68 (20) ◽  
pp. 8210-8220 ◽  
Author(s):  
Bharat Joshi ◽  
Scott S. Strugnell ◽  
Jacky G. Goetz ◽  
Liliana D. Kojic ◽  
Michael E. Cox ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Cell ◽  
Focal Adhesion ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Caveolin 1

scholarly journals The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Solange Rivas ◽  
Patricio Silva ◽  
Montserrat Reyes ◽  
Hugo Sepúlveda ◽  
Luis Solano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Migration ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Proximal Promoter ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Tumor Cell Migration ◽  
Rab Protein

AbstractTumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that these events do not involve changes in Rab protein expression, suggesting the participation of intermediate activators. Here, we identified ALS2, a guanine nucleotide exchange factor that is upregulated in cancer, as responsible for increased Rab5-GTP loading, cell migration and metastasis in hypoxia. Specifically, hypoxia augmented ALS2 mRNA and protein levels, and these events involved HIF-1α-dependent transcription, as shown by RNAi, pharmacological inhibition, chromatin immunoprecipitation and bioinformatics analyses, which identified a functional HIF-1α-binding site in the proximal promoter region of ALS2. Moreover, ALS2 and Rab5 activity were elevated both in a model of endogenous HIF-1α stabilization (renal cell carcinoma) and by following expression of stable non-hydroxylatable HIF-1α. Strikingly, ALS2 upregulation in hypoxia was required for Rab5 activation, tumor cell migration and invasion, as well as experimental metastasis in C57BL/6 mice. Finally, immunohistochemical analyses in patient biopsies with renal cell carcinoma showed that elevated HIF-1α correlates with increased ALS2 expression. Hence, this study identifies ALS2 as a novel hypoxia-inducible gene associated with tumor progression and metastasis.

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