scholarly journals Conditional Inactivation of the CXCR4 Receptor in Osteoprecursors Reduces Postnatal Bone Formation Due to Impaired Osteoblast Development

2011 ◽  
Vol 286 (30) ◽  
pp. 26794-26805 ◽  
Author(s):  
Wei Zhu ◽  
Gang Liang ◽  
Zhiping Huang ◽  
Stephen B. Doty ◽  
Adele L. Boskey
Keyword(s):  
Bone Formation ◽  
Cxcr4 Receptor ◽  
Conditional Inactivation ◽  
Osteoblast Development

scholarly journals Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

2007 ◽  
Vol 120 (16) ◽  
pp. 2785-2795 ◽  
Author(s):  
L. S. H. Nissen-Meyer ◽  
R. Jemtland ◽  
V. T. Gautvik ◽  
M. E. Pedersen ◽  
R. Paro ◽  
...  
Keyword(s):  
Bone Formation ◽  
Osteoblast Development

scholarly journals Conditional Inactivation of Noggin in the Postnatal Skeleton Causes Osteopenia

Endocrinology ◽  
2012 ◽  
Vol 153 (4) ◽  
pp. 1616-1626 ◽  
Author(s):  
Ernesto Canalis ◽  
Lisa J. Brunet ◽  
Kristen Parker ◽  
Stefano Zanotti
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Bone Morphogenetic Proteins ◽  
Detrimental Effect ◽  
Bone Volume ◽  
Developmental Defects ◽  
Femoral Length ◽  
Conditional Inactivation ◽  
Skeletal Homeostasis ◽  
Old Mice

Noggin is an antagonist of bone morphogenetic proteins (BMP), and its overexpression causes suppressed osteoblastogenesis and osteopenia. Global inactivation of Noggin results in severe developmental defects and prenatal lethality, but the consequences of the conditional inactivation of Noggin on the postnatal skeleton are not known. To study the function of noggin in osteoblasts, we generated tissue-specific null Noggin mice by mating Noggin conditional mice, where the Noggin allele is flanked by loxP sequences, with mice expressing the Cre recombinase under the control of the osteocalcin promoter (Oc-Cre). Noggin conditional null mice exhibited decreased weight, shortened femoral length, and generalized osteopenia. Bone histomorphometric and microarchitectural analyses of distal femurs revealed decreased bone volume due to a reduced number of trabeculae in 1- and 3-month-old Noggin conditional null mice. Vertebral microarchitecture confirmed the osteopenia observed in Noggin conditional null mice. Osteoclast number was increased in 1-month-old male Noggin conditional null mice, and bone formation was increased in 3-month-old mice, but female mice did not exhibit increased bone remodeling. In conclusion, Noggin inactivation causes osteopenia, suggesting that BMP in excess have a detrimental effect on bone or that noggin has a BMP-independent role in skeletal homeostasis.

Dietary Calcium Supplementation Suppresses Bone Formation in Magnesium-Deficient Rats

2006 ◽  
Vol 76 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Hiroshi Matsuzaki ◽  
Misao Miwa
Keyword(s):  
Bone Formation ◽  
Calcium Supplementation ◽  
Control Diet ◽  
Formation Rate ◽  
Dietary Calcium ◽  
Mineral Apposition Rate ◽  
Control Group ◽  
Deficient Diet ◽  
Bone Formation Rate ◽  
Male Wistar Rats

The purpose of this study was to clarify the effects of dietary calcium (Ca) supplementation on bone metabolism of magnesium (Mg)-deficient rats. Male Wistar rats were randomized by weight into three groups, and fed a control diet (control group), a Mg-deficient diet (Mg- group) or a Mg-deficient diet having twice the control Ca concentrations (Mg-2Ca group) for 14 days. Trabecular bone volume was significantly lower in the Mg - and Mg-2Ca groups than in the control group. Trabecular number was also significantly lower in the Mg - and Mg-2Ca groups than in the control group. Mineralizing bone surface, mineral apposition rate (MAR), and surface referent bone formation rate (BFR/BS) were significantly lower in the Mg - and Mg-2Ca groups than in the control group. Furthermore, MAR and BFR/BS were significantly lower in the Mg-2Ca group than in the Mg - group. These results suggest that dietary Ca supplementation suppresses bone formation in Mg-deficient rats.

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