scholarly journals Adenosine Monophosphate-activated Protein Kinase Induces Cholesterol Efflux from Macrophage-derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-deficient Mice

2010 ◽  
Vol 285 (43) ◽  
pp. 33499-33509 ◽  
Author(s):  
Dan Li ◽  
Duan Wang ◽  
Yun Wang ◽  
Wenhua Ling ◽  
Xiang Feng ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Apolipoprotein E ◽  
Cholesterol Efflux ◽  
Adenosine Monophosphate ◽  
Foam Cells ◽  
Deficient Mice

scholarly journals PPARγ1-Induced Caveolin-1 Enhances Cholesterol Efflux and Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice

2009 ◽  
Vol 47 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Qin Hu ◽  
Xian-jun Zhang ◽  
Chun-xi Liu ◽  
Xu-ping Wang ◽  
Yun Zhang
Keyword(s):  
Apolipoprotein E ◽  
Cholesterol Efflux ◽  
Caveolin 1 ◽  
Deficient Mice

Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice

2021 ◽  
Author(s):  
Patricia Snarski ◽  
Sergiy Sukhanov ◽  
Tadashi Yoshida ◽  
Yusuke Higashi ◽  
Svitlana Danchuk ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Cholesterol Efflux ◽  
Foam Cell ◽  
Foam Cells ◽  
Peritoneal Macrophages ◽  
Cellular Growth ◽  
Foam Cell Formation ◽  
Atherosclerotic Burden ◽  
Lipid Efflux ◽  
Deficient Mice

Objective: IGF-1 (insulin-like growth factor 1) exerts pleiotropic effects including promotion of cellular growth, differentiation, survival, and anabolism. We have shown that systemic IGF-1 administration reduced atherosclerosis in Apoe −/ − (apolipoprotein E deficient) mice, and this effect was associated with a reduction in lesional macrophages and a decreased number of foam cells in the plaque. Almost all cell types secrete IGF-1, but the effect of macrophage-derived IGF-1 on the pathogenesis of atherosclerosis is poorly understood. We hypothesized that macrophage-derived IGF-1 will reduce atherosclerosis. Approach and Results: We created macrophage-specific IGF-1 overexpressing mice on an Apoe − / − background. Macrophage-specific IGF-1 overexpression reduced plaque macrophages, foam cells, and atherosclerotic burden and promoted features of stable atherosclerotic plaque. Macrophage-specific IGF1 mice had a reduction in monocyte infiltration into plaque, decreased expression of CXCL12 (CXC chemokine ligand 12), and upregulation of ABCA1 (ATP-binding cassette transporter 1), a cholesterol efflux regulator, in atherosclerotic plaque and in peritoneal macrophages. IGF-1 prevented oxidized lipid-induced CXCL12 upregulation and foam cell formation in cultured THP-1 macrophages and increased lipid efflux. We also found an increase in cholesterol efflux in macrophage-specific IGF1–derived peritoneal macrophages. Conclusions: Macrophage IGF-1 overexpression reduced atherosclerotic burden and increased features of plaque stability, likely via a reduction in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.

scholarly journals Reduced ABCA1-Mediated Cholesterol Efflux and Accelerated Atherosclerosis in Apolipoprotein E–Deficient Mice Lacking Macrophage-Derived ACAT1

Circulation ◽  
2005 ◽  
Vol 111 (18) ◽  
pp. 2373-2381 ◽  
Author(s):  
Yan Ru Su ◽  
Dwayne E. Dove ◽  
Amy S. Major ◽  
Alyssa H. Hasty ◽  
Branden Boone ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Cholesterol Efflux ◽  
Accelerated Atherosclerosis ◽  
Deficient Mice
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