scholarly journals Soluble Repulsive Guidance Molecule c/Hemojuvelin Is a Broad Spectrum Bone Morphogenetic Protein (BMP) Antagonist and Inhibits both BMP2- and BMP6-mediated Signaling and Gene Expression

2010 ◽  
Vol 285 (32) ◽  
pp. 24783-24792 ◽  
Author(s):  
Mahta Nili ◽  
Ujwal Shinde ◽  
Peter Rotwein
Keyword(s):  
Gene Expression ◽  
Bone Morphogenetic Protein ◽  
Broad Spectrum ◽  
Morphogenetic Protein ◽  
Repulsive Guidance Molecule ◽  
Guidance Molecule ◽  
Bmp Antagonist

scholarly journals Repulsive Guidance Molecule RGMa Alters Utilization of Bone Morphogenetic Protein (BMP) Type II Receptors by BMP2 and BMP4

2007 ◽  
Vol 282 (25) ◽  
pp. 18129-18140 ◽  
Author(s):  
Yin Xia ◽  
Paul B. Yu ◽  
Yisrael Sidis ◽  
Hideyuki Beppu ◽  
Kenneth D. Bloch ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Type Ii ◽  
Morphogenetic Protein ◽  
Repulsive Guidance Molecule ◽  
Guidance Molecule

scholarly journals Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor

2005 ◽  
Vol 280 (33) ◽  
pp. 29820-29827 ◽  
Author(s):  
Jodie L. Babitt ◽  
Ying Zhang ◽  
Tarek A. Samad ◽  
Yin Xia ◽  
Jie Tang ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein ◽  
Repulsive Guidance Molecule ◽  
Guidance Molecule

scholarly journals Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

2015 ◽  
Vol 22 (6) ◽  
pp. 458-465 ◽  
Author(s):  
Eleanor G Healey ◽  
Benjamin Bishop ◽  
Jonathan Elegheert ◽  
Christian H Bell ◽  
Sergi Padilla-Parra ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Morphogenetic Protein ◽  
Repulsive Guidance Molecule ◽  
Guidance Molecule

scholarly journals Localization and Action of Dragon (Repulsive Guidance Molecule b), a Novel Bone Morphogenetic Protein Coreceptor, throughout the Reproductive Axis

Endocrinology ◽  
2005 ◽  
Vol 146 (8) ◽  
pp. 3614-3621 ◽  
Author(s):  
Yin Xia ◽  
Yisrael Sidis ◽  
Abir Mukherjee ◽  
Tarek A. Samad ◽  
Gary Brenner ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Reproductive Axis ◽  
Morphogenetic Protein ◽  
Repulsive Guidance Molecule ◽  
Guidance Molecule

scholarly journals Expression Profiles of the Progesterone Receptor, Cyclooxygenase-2, Growth Differentiation Factor 9, and Bone Morphogenetic Protein 15 Transcripts in the Canine Oviducts during the Oestrous Cycle

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 454
Author(s):  
Jaime Palomino ◽  
Javiera Flores ◽  
Georges Ramirez ◽  
Victor H. Parraguez ◽  
Monica De los Reyes
Keyword(s):  
Gene Expression ◽  
Bone Morphogenetic Protein ◽  
Cyclooxygenase 2 ◽  
Oestrous Cycle ◽  
Progesterone Concentration ◽  
Plasma Progesterone ◽  
Morphogenetic Protein ◽  
Growth Differentiation Factor 9 ◽  
Bone Morphogenetic Protein 15 ◽  
Cox 2

The gene expression in the canine oviduct, where oocyte maturation, fertilization, and early embryonic development occur, is still elusive. This study determined the oviductal expression of (PR), cyclooxygenase-2 (COX-2), growth differentiation factor 9 (GDF-9), and bone morphogenetic protein 15 (BMP-15) during the canine oestrous cycle. Samples were collected from bitches at anoestrus (9), proestrus (7), oestrus (8), and dioestrus (11), after routine ovariohysterectomy and the ovarian surface structures and plasma progesterone concentration evaluated the physiological status of each donor. The oviductal cells were isolated and pooled. Total RNA was isolated, and gene expression was assessed by qPCR followed by analysis using the t-test and ANOVA. The PR mRNA increased (P < 0.05) from the anoestrus to dioestrus with the plasma progesterone concentration (r = 0.8). COX-2 mRNA expression was low in the anoestrus and proestrus, and negligible in the oestrus, while it was around 10-fold higher (P < 0.05) in the dioestrus. The GDF-9 mRNA was expressed during all phases of the oestrous cycle and was most abundant (P < 0.05) during oestrus phase. The BMP-15 mRNA decreased (P < 0.05) in the anoestrus and proestrus phases. Thus, the transcripts were differentially expressed in a stage-dependent manner, suggesting the importance of oestrous cycle regulation for successful reproduction in dogs.

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