scholarly journals CTG/CAG Repeat Instability Is Modulated by the Levels of Human DNA Ligase I and Its Interaction with Proliferating Cell Nuclear Antigen

2009 ◽  
Vol 284 (39) ◽  
pp. 26631-26645 ◽  
Author(s):  
Arturo López Castel ◽  
Alan E. Tomkinson ◽  
Christopher E. Pearson
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Cag Repeat ◽  
Nuclear Antigen ◽  
Dna Ligase ◽  
Repeat Instability ◽  
Human Dna ◽  
Dna Ligase I ◽  
Proliferating Cell

scholarly journals Proliferating cell nuclear antigen restores the enzymatic activity of a DNA ligase I deficient in DNA binding

FEBS Open Bio ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 659-674 ◽  
Author(s):  
Carlos H. Trasviña-Arenas ◽  
Cesar S. Cardona-Felix ◽  
Elisa Azuara-Liceaga ◽  
Corina Díaz-Quezada ◽  
Luis G. Brieba
Keyword(s):  
Dna Binding ◽  
Enzymatic Activity ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Dna Ligase ◽  
Dna Ligase I ◽  
Proliferating Cell

scholarly journals DNA Ligase I and Proliferating Cell Nuclear Antigen Form a Functional Complex

2001 ◽  
Vol 276 (27) ◽  
pp. 24817-24825 ◽  
Author(s):  
Samson Tom ◽  
Leigh A. Henricksen ◽  
Min S. Park ◽  
Robert A. Bambara
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Dna Ligase ◽  
Dna Ligase I ◽  
Functional Complex ◽  
Proliferating Cell

scholarly journals The Effect of DNA Replication Mutations on CAG Tract Stability in Yeast

Genetics ◽  
1999 ◽  
Vol 152 (3) ◽  
pp. 953-963 ◽  
Author(s):  
Jill Kuglin Schweitzer ◽  
Dennis M Livingston
Keyword(s):  
Dna Replication ◽  
Proliferating Cell Nuclear Antigen ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Nuclear Antigen ◽  
Temperature Sensitive ◽  
Simple Repeats ◽  
Proliferating Cell ◽  
Lagging Strand ◽  
Palindromic Sequences

AbstractCAG repeat tracts are unstable in yeast, leading to frequent contractions and infrequent expansions in repeat tract length. To compare CAG repeats to other simple repeats and palindromic sequences, we examined the effect of DNA replication mutations, including alleles of pol α, pol δ, pol ϵ, and PCNA (proliferating cell nuclear antigen), on tract stability. Among the polymerase mutations, the pol δ mutation (pol3-14) destabilizes tracts with either CAG or CTG as the lagging strand template. One pol α mutation, pol1-1, destabilizes the orientation with CAG as the lagging strand template, but it has little effect on the CTG orientation. In contrast, the pol1-17 mutation has no effect on either orientation. Similarly, mutations in the proofreading functions of pol δ and pol ϵ, as well as a temperature-sensitive pol ϵ mutation, pol2-18, have no effect on tract stability. Three PCNA mutations, pol30-52, pol30-79, and pol30-90, all have drastic effects on tract stability. Of the three, pol30-52 is unique in yielding small tract changes that are indicative of an impairment in mismatch repair. These results show that while CAG repeats are destabilized by many of the same mutations that destabilize other simple repeats, they also have some behaviors that are suggestive of their potential to form hairpin structures.

scholarly journals Proliferating Cell Nuclear Antigen-dependent Coordination of the Biological Functions of Human DNA Polymerase ι

2004 ◽  
Vol 279 (46) ◽  
pp. 48360-48368 ◽  
Author(s):  
Antonio E. Vidal ◽  
Patricia Kannouche ◽  
Vladimir N. Podust ◽  
Wei Yang ◽  
Alan R. Lehmann ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Biological Functions ◽  
Human Dna ◽  
Proliferating Cell ◽  
Dna Polymerase Ι
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