Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway

Lei Xu; Dai Fukumura; Rakesh K. Jain

doi:10.1074/jbc.m108347200

Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m108347200 ◽

2001 ◽

Vol 277 (13) ◽

pp. 11368-11374 ◽

Cited By ~ 195

Author(s):

Lei Xu ◽

Dai Fukumura ◽

Rakesh K. Jain

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Signaling Pathway ◽

Mapk Signaling ◽

Extracellular Ph ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Acidic Extracellular Ph ◽

Endothelial Growth Factor

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Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway. Mechanism of low pH-induced VEGF.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(20)85218-1 ◽

2002 ◽

Vol 277 (21) ◽

pp. 19242

Author(s):

Lei Xu ◽

Dai Fukumura ◽

Rakesh K. Jain

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Signaling Pathway ◽

Mapk Signaling ◽

Low Ph ◽

Extracellular Ph ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Acidic Extracellular Ph ◽

Endothelial Growth Factor

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Two Novel Heparin-binding Vascular Endothelial Growth Factor Splices, L-VEGF144 and L-VEGF138, are Expressed in Human Glioblastoma Cells

Current Neurovascular Research ◽

10.2174/1567202613666160525115446 ◽

2016 ◽

Vol 13 (3) ◽

pp. 207-218 ◽

Cited By ~ 4

Author(s):

Chiung-Chyi Shen ◽

Wen-Yu Cheng ◽

Ming-Tsang Chiao ◽

Yea-Jiuan Liang ◽

Tsuo-Fei Mao ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Vascular Endothelial ◽

Heparin Binding ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Human Glioblastoma Cells ◽

Endothelial Growth Factor

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Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells

Brain Tumor Pathology ◽

10.1007/bf02478931 ◽

2002 ◽

Vol 19 (2) ◽

pp. 77-81 ◽

Cited By ~ 46

Author(s):

Hiroki Sawa ◽

Hiromi Murakami ◽

Yoko Ohshima ◽

Masahiro Murakami ◽

Ichiro Yamazaki ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Histone Deacetylase ◽

Sodium Butyrate ◽

Histone Deacetylase Inhibitors ◽

Trichostatin A ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Endothelial Growth Factor

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8-Cl-cAMP and tiazofurin affect vascular endothelial growth factor production and glial fibrillary acidic protein expression in human glioblastoma cells

Anti-Cancer Drugs ◽

10.1097/00001813-200010000-00014 ◽

2000 ◽

Vol 11 (9) ◽

pp. 765-770 ◽

Cited By ~ 8

Author(s):

Ksenija Drabek ◽

Milica Pešic´ ◽

Vesna Piperski ◽

Sabera Ruždijic´ ◽

Ljubica Medic´-Mijačevic´ ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Glial Fibrillary Acidic Protein ◽

Protein Expression ◽

Acidic Protein ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Growth Factor Production ◽

Endothelial Growth Factor

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Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells

Scientific Reports ◽

10.1038/srep44075 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 12

Author(s):

Majid Momeny ◽

Farima Moghaddaskho ◽

Narges K. Gortany ◽

Hassan Yousefi ◽

Zahra Sabourinejad ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptors ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Human Glioblastoma Cells ◽

Endothelial Growth Factor

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Vascular endothelial growth factor-induced expression of its receptors and activation of the MAPK signaling pathway during ovine oocyte maturation in vitro

Theriogenology ◽

10.1016/j.theriogenology.2012.06.001 ◽

2012 ◽

Vol 78 (6) ◽

pp. 1350-1360 ◽

Cited By ~ 13

Author(s):

L. Yan ◽

H. Luo ◽

X. Gao ◽

K. Liu ◽

Y. Zhang

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Signaling Pathway ◽

Oocyte Maturation ◽

Mapk Signaling ◽

Vascular Endothelial ◽

Induced Expression ◽

Maturation In Vitro ◽

Endothelial Growth Factor

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Cell-specific but p53-independent Regulation of Vascular Endothelial Growth Factor Expression by Interferons in Human Glioblastoma Cells

Journal of Neuro-Oncology ◽

10.1007/s11060-005-6498-5 ◽

2005 ◽

Vol 76 (3) ◽

pp. 219-225 ◽

Cited By ~ 2

Author(s):

Yongxue Yao ◽

Toshihiko Kubota ◽

Kazufumi Sato ◽

Hiroaki Takeuchi ◽

Yuji Handa ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Factor Expression ◽

Growth Factor Expression ◽

Human Glioblastoma Cells ◽

Endothelial Growth Factor

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Vascular endothelial growth factor over-expressed mesenchymal stem cells-conditioned media ameliorate palmitate-induced diabetic endothelial dysfunction through PI-3K/AKT/m-TOR/eNOS and p38/MAPK signaling pathway

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.06.129 ◽

2018 ◽

Vol 106 ◽

pp. 491-498 ◽

Cited By ~ 10

Author(s):

Tianwei Xu ◽

Zhengbing Lv ◽

Qiuhua Chen ◽

Min Guo ◽

Xufang Wang ◽

...

Keyword(s):

Stem Cells ◽

Vascular Endothelial Growth Factor ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Endothelial Dysfunction ◽

Signaling Pathway ◽

P38 Mapk ◽

Mapk Signaling ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Paeonol enhances thrombus recanalization by inducing vascular endothelial growth factor 165 via ERK1/2 MAPK signaling pathway

Molecular Medicine Reports ◽

10.3892/mmr.2016.5135 ◽

2016 ◽

Vol 13 (6) ◽

pp. 4853-4858 ◽

Cited By ~ 4

Author(s):

SONGSHAN YE ◽

XIANJUAN LIU ◽

BINGYU MAO ◽

LEI YANG ◽

NUAN LIU

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Signaling Pathway ◽

Mapk Signaling ◽

Mapk Signaling Pathway ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells

Biochemical Pharmacology ◽

10.1016/j.bcp.2006.03.020 ◽

2006 ◽

Vol 72 (1) ◽

pp. 19-31 ◽

Cited By ~ 90

Author(s):

Stefania Merighi ◽

Annalisa Benini ◽

Prisco Mirandola ◽

Stefania Gessi ◽

Katia Varani ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Hypoxia Inducible Factor ◽

Vascular Endothelial ◽

Glioblastoma Cells ◽

Human Glioblastoma ◽

Hypoxia Inducible Factor 1 ◽

Factor Expression ◽

Growth Factor Expression ◽

Endothelial Growth Factor

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