scholarly journals Tumor Suppressor p53 Mediates Apoptotic Cell Death Triggered by Cyclosporin A

2002 ◽  
Vol 277 (16) ◽  
pp. 14102-14108 ◽  
Author(s):  
Beata Pyrzynska ◽  
Manuel Serrano ◽  
Carlos Martı́nez-A. ◽  
Bozena Kaminska
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Cyclosporin A ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Tumor Suppressor P53

scholarly journals p53: The Attractive Tumor Suppressor in the Cancer Research Field

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Toshinori Ozaki ◽  
Akira Nakagawara
Keyword(s):  
Cell Cycle ◽  
Cancer Research ◽  
Cell Death ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Apoptotic Cell ◽  
Genetic Alterations ◽  
Research Field ◽  
Apoptotic Cell Death ◽  
Cycle Arrest

p53 is one of the most studied tumor suppressors in the cancer research field. Of note, over 50% of human tumors carry loss of function mutations, and thus p53 has been considered to be a classical Knudson-type tumor suppressor. From the functional point of view, p53 is a nuclear transcription factor to transactivate a variety of its target genes implicated in the induction of cell cycle arrest, DNA repair, and apoptotic cell death. In response to cellular stresses such as DNA damage, p53 is activated and promotes cell cycle arrest followed by the replacement of DNA lesions and/or apoptotic cell death. Therefore, p53 is able to maintain the genomic integrity to prevent the accumulation of genetic alterations, and thus stands at a crossroad between cell survival and cell death. In this paper, we describe a variety of molecular mechanisms behind the regulation of p53.

scholarly journals KIF1Bβ Functions as a Haploinsufficient Tumor Suppressor Gene Mapped to Chromosome 1p36.2 by Inducing Apoptotic Cell Death

2008 ◽  
Vol 283 (36) ◽  
pp. 24426-24434 ◽  
Author(s):  
Arasambattu K. Munirajan ◽  
Kiyohiro Ando ◽  
Akira Mukai ◽  
Masato Takahashi ◽  
Yusuke Suenaga ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Apoptotic Cell ◽  
Suppressor Gene ◽  
Apoptotic Cell Death

scholarly journals JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila

2005 ◽  
Vol 13 (7) ◽  
pp. 1110-1122 ◽  
Author(s):  
J H Lee ◽  
H Koh ◽  
M Kim ◽  
J Park ◽  
S Y Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Jnk Pathway
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