scholarly journals Sp1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p21WAF1/Cip1Gene by the p53 Tumor Suppressor Protein

2001 ◽  
Vol 276 (31) ◽  
pp. 29116-29125 ◽  
Author(s):  
George Koutsodontis ◽  
Ioannis Tentes ◽  
Paraskevi Papakosta ◽  
Aristidis Moustakas ◽  
Dimitris Kardassis
Keyword(s):  
Tumor Suppressor ◽  
Transcriptional Activation ◽  
Kinase Inhibitor ◽  
Critical Role ◽  
Tumor Suppressor Protein ◽  
Cyclin Dependent Kinase ◽  
P53 Tumor Suppressor ◽  
Cyclin Dependent Kinase Inhibitor ◽  
P53 Tumor Suppressor Protein

VRML in Cancer Research: Local Changes in Binding Properties of Wild Type and Mutated p53 Tumor Suppressor Protein

1997 ◽  
Vol 3 (9) ◽  
pp. 382-385
Author(s):  
Gerd Moeckel ◽  
Matthias Keil ◽  
Monica Hollstein ◽  
Bertold Spiegelhalder ◽  
Helmut Bartsch ◽  
...  
Keyword(s):  
Cancer Research ◽  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
Wild Type ◽  
Binding Properties ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Protein

Functional Loss of p21/Waf-1 in a Case of Benign Canine Multicentric Melanoma

1998 ◽  
Vol 35 (2) ◽  
pp. 94-101 ◽  
Author(s):  
M. G. Ritt ◽  
J. Wojcieszyn ◽  
J. F. Modiano
Keyword(s):  
Tumor Suppressor ◽  
Cell Cycle Progression ◽  
Kinase Inhibitor ◽  
P53 Gene ◽  
Tumor Formation ◽  
Cyclin Dependent Kinase ◽  
P53 Expression ◽  
Functional Loss ◽  
Normal Tissues ◽  
Cyclin Dependent Kinase Inhibitor

Mutations of tumor suppressor genes remove mechanisms that normally arrest proliferation of transformed cells, resulting in tumor formation. The p53 gene product functions as a tumor suppressor that induces p21/Waf-1, the 21-kDa product of the waf-1/cip-1/mda-6 gene. p21/Waf-1 is a pan-cyclin-dependent kinase inhibitor that arrests cell cycle progression under a variety of circumstances. We examined tissues from a dog with multiple primary pigmented proliferative lesions (benign, multicentric melanoma consisting of three distinct dermal lesions and a matrical cyst) for p21/Waf-1 and p53 expression by immunohistochemistry and immunoblotting. p21/Waf-1 and p-53 proteins were undetectable in the tumor cells and in the cyst but were present in adjacent normal tissues. Abundant cyclin-dependent kinase 4 (Cdk4), a protein related functionally to p21/Waf-1, also was present in the cyst. A somatic mutation of the waf-1 gene or of the p53 gene may have resulted in the loss of p21/Waf-1 expression in a common precursor of pigment-producing cells from the affected dog. Furthermore, this functional loss of p21/Waf-1 may play an important role in the genesis of canine benign melanoma.

The P53 Tumor Suppressor Protein

1995 ◽  
pp. 407-418 ◽  
Author(s):  
Ettore Appella ◽  
Kazuyasu Sakaguchi ◽  
Hiroshi Sakamoto ◽  
Marc S. Lewis ◽  
James G. Omichinski ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Protein
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