scholarly journals Implications for Isoform-selective Inhibitor Design Derived from the Binding Mode of Bulky Isothioureas to the Heme Domain of Endothelial Nitric-oxide Synthase

2001 ◽  
Vol 276 (28) ◽  
pp. 26486-26491 ◽  
Author(s):  
C. S. Raman ◽  
Huiying Li ◽  
Pavel Martásek ◽  
Boga Ramesh Babu ◽  
Owen W. Griffith ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Binding Mode ◽  
Selective Inhibitor ◽  
Inhibitor Design ◽  
Heme Domain ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Structures of the Neuronal and Endothelial Nitric Oxide Synthase Heme Domain withd-Nitroarginine-Containing Dipeptide Inhibitors Bound†

Biochemistry ◽  
2004 ◽  
Vol 43 (18) ◽  
pp. 5181-5187 ◽  
Author(s):  
Mack Flinspach ◽  
Huiying Li ◽  
Joumana Jamal ◽  
Weiping Yang ◽  
Hui Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Heme Domain ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas

2000 ◽  
Vol 81 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Huiying Li ◽  
C.S. Raman ◽  
Pavel Martásek ◽  
Vladimir Král ◽  
Bettie Sue S. Masters ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Active Site ◽  
Endothelial Nitric Oxide Synthase ◽  
Heme Domain ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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