scholarly journals MKK6/3 and p38 MAPK Pathway Activation Is Not Necessary for Insulin-induced Glucose Uptake but Regulates Glucose Transporter Expression

2001 ◽  
Vol 276 (23) ◽  
pp. 19800-19806 ◽  
Author(s):  
Midori Fujishiro ◽  
Yukiko Gotoh ◽  
Hideki Katagiri ◽  
Hideyuki Sakoda ◽  
Takehide Ogihara ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
P38 Mapk ◽  
Glucose Transporter ◽  
Mapk Pathway ◽  
P38 Mapk Pathway ◽  
Pathway Activation ◽  
Transporter Expression

scholarly journals Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Guilherme Lopes Gonçalves ◽  
Juliana Martins Costa-Pessoa ◽  
Karina Thieme ◽  
Bruna Bezerra Lins ◽  
Maria Oliveira-Souza
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Pkc Delta ◽  
P38 Mapk Pathway ◽  
Pathway Activation

Glypican-3 (GPC3) inhibits metastasis development promoting dormancy in breast cancer cells by p38 MAPK pathway activation

2020 ◽  
Vol 99 (6) ◽  
pp. 151096 ◽  
Author(s):  
Macarena Guereño ◽  
Magali Delgado Pastore ◽  
Ana Clara Lugones ◽  
Magalí Cercato ◽  
Laura Todaro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Breast Cancer Cells ◽  
Mapk Pathway ◽  
P38 Mapk Pathway ◽  
Pathway Activation ◽  
Metastasis Development

scholarly journals Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2+-dependent AMPK–p38 MAPK pathway in C2C12 skeletal muscle cells

2015 ◽  
Vol 54 (3) ◽  
pp. 251-262 ◽  
Author(s):  
Jung Ok Lee ◽  
Nami Kim ◽  
Hye Jeong Lee ◽  
Yong Woo Lee ◽  
Joong Kwan Kim ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Glucose Uptake ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Ampk Phosphorylation ◽  
P38 Mapk Pathway ◽  
C2c12 Skeletal Muscle Cells

Visfatin is a novel adipocytokine produced by visceral fat. In the present study, visfatin increased AMP-activated protein kinase (AMPK) phosphorylation in mouse C2C12 skeletal muscle cells. It also increased phosphorylation of the insulin receptor, whose knockdown blocked visfatin-induced AMPK phosphorylation and glucose uptake. Visfatin stimulated glucose uptake in differentiated skeletal muscle cells. However, inhibition of AMPKα2 with an inhibitor or with knockdown of AMPKα2 using siRNA blocked visfatin-induced glucose uptake, which indicates that visfatin stimulates glucose uptake through the AMPKα2 pathway. Visfatin increased the intracellular Ca2+concentration. STO-609, a calmodulin-dependent protein kinase kinase inhibitor, blocked visfatin-induced AMPK phosphorylation and glucose uptake. Visfatin-mediated activation of p38 MAPK was AMPKα2-dependent. Furthermore, both inhibition and knockdown of p38 MAPK blocked visfatin-induced glucose uptake. Visfatin increased glucose transporter type 4 (GLUT4) mRNA and protein levels. In addition, visfatin stimulated the translocation of GLUT4 to the plasma membrane, and this effect was suppressed by AMPKα2 inhibition. The present results indicate that visfatin plays an important role in glucose metabolism via the Ca2+-mediated AMPK–p38 MAPK pathway.

scholarly journals Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Vanessa Gerolde Cardoso ◽  
Guilherme Lopes Gonçalves ◽  
Juliana Martins Costa-Pessoa ◽  
Karina Thieme ◽  
Bruna Bezerra Lins ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Angiotensin Ii ◽  
Endoplasmic Reticulum Stress ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway ◽  
Pathway Activation

Role of the p38 MAPK Pathway in Induction of iNOS Expression in Human Leukocytes

2008 ◽  
Vol 56 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Ewa Jablonska ◽  
Wioletta Ratajczak ◽  
Jakub Jablonski
Keyword(s):  
P38 Mapk ◽  
Mapk Pathway ◽  
Inos Expression ◽  
Human Leukocytes ◽  
P38 Mapk Pathway

Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway

2021 ◽  
Author(s):  
Lingfan Xiong ◽  
Wenhao Guo ◽  
Yong Yang ◽  
Danping Gao ◽  
Jun Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
P38 Mapk Pathway
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