scholarly journals CYR61 Stimulates Human Skin Fibroblast Migration through Integrin αvβ5and Enhances Mitogenesis through Integrin αvβ3, Independent of Its Carboxyl-terminal Domain

2001 ◽  
Vol 276 (24) ◽  
pp. 21943-21950 ◽  
Author(s):  
Tatiana M. Grzeszkiewicz ◽  
Deborah J. Kirschling ◽  
Ningyu Chen ◽  
Lester F. Lau
Keyword(s):  
Human Skin ◽  
Skin Fibroblast ◽  
Integrin Αvβ3 ◽  
Human Skin Fibroblast ◽  
Fibroblast Migration ◽  
Terminal Domain ◽  
Carboxyl Terminal Domain ◽  
Carboxyl Terminal

Stimulation of human skin fibroblast migration by the neuropeptide secretoneurin

1996 ◽  
Vol 304 (1-3) ◽  
pp. 135-139 ◽  
Author(s):  
Christian M. Kähler ◽  
R. Bellmann ◽  
N. Reinisch ◽  
P. Schratzberger ◽  
B. Gruber ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblast ◽  
Human Skin Fibroblast ◽  
Fibroblast Migration ◽  
Stimulation Of

scholarly journals Correction: EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

2017 ◽  
Vol 474 (16) ◽  
pp. 2901-2902 ◽  
Author(s):  
Cong Cao ◽  
Yun Sun ◽  
Sarah Healey ◽  
Zhigang Bi ◽  
Gang Hu ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblast ◽  
Human Skin Fibroblast ◽  
Aquaporin 3 ◽  
Fibroblast Migration

scholarly journals EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

2006 ◽  
Vol 400 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Cong Cao ◽  
Yun Sun ◽  
Sarah Healey ◽  
Zhigang Bi ◽  
Gang Hu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Human Skin ◽  
Skin Fibroblast ◽  
Kinase Inhibitor ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblast ◽  
Human Skin Fibroblasts ◽  
Aquaporin 3 ◽  
Fibroblast Migration ◽  
Normal Wound Healing

AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin. Here, we demonstrate that AQP3 is also expressed in cultured human skin fibroblasts, which under normal wound healing processes migrate from surrounding tissues to close the wound. EGF (epidermal growth factor), which induced fibroblast migration, also induced AQP3 expression in a time- and dose-dependent manner. CuSO4 and NiCl2, previously known as AQP3 water transport inhibitors, as well as two other bivalent heavy metals Mn2+ and Co2+, inhibited EGF-induced cell migration in human skin fibroblasts. AQP3 knockdown by small interfering RNA inhibited EGF-induced AQP3 expression and cell migration. Furthermore, an EGFR (EGF receptor) kinase inhibitor, PD153035, blocked EGF-induced AQP3 expression and cell migration. MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK inhibitor U0126 and PI3K (phosphoinositide 3-kinase) inhibitor LY294002 also inhibited EGF-induced AQP3 expression and cell migration. Collectively, our findings show for the first time that AQP3 is expressed in human skin fibroblasts and that EGF induces AQP3 expression via EGFR, PI3K and ERK signal transduction pathways. We have provided evidence for a novel role of AQP3 in human skin fibroblast cell migration, which occurs during normal wound healing.

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