scholarly journals Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats

2001 ◽  
Vol 276 (44) ◽  
pp. 40567-40573 ◽  
Author(s):  
Joost J. F. P. Luiken ◽  
Yoga Arumugam ◽  
David J. Dyck ◽  
Rhonda C. Bell ◽  
Maurice M. L. Pelsers ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Uptake ◽  
Zucker Rats ◽  
Acid Uptake ◽  
Obese Zucker Rats

scholarly journals Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats

Diabetes ◽  
2001 ◽  
Vol 50 (6) ◽  
pp. 1389-1396 ◽  
Author(s):  
Lorraine Patricia Turcotte ◽  
Jason Richard Swenberger ◽  
Michelle Zavitz Tucker ◽  
Alice Jane Yee
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Fatty Acid Uptake ◽  
Zucker Rats ◽  
Acid Uptake ◽  
Insulin Resistant ◽  
Obese Zucker Rats

Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle

2007 ◽  
Vol 293 (2) ◽  
pp. E566-E575 ◽  
Author(s):  
Xiao-Xia Han ◽  
Adrian Chabowski ◽  
Narendra N. Tandon ◽  
Jorge Calles-Escandon ◽  
Jan F. C. Glatz ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Metabolism ◽  
Fatty Acid Uptake ◽  
Zucker Rats ◽  
Acid Oxidation ◽  
Acid Uptake ◽  
Rat Muscle ◽  
Fatty Acid Transporter ◽  
Obese Zucker Rats

We examined, in muscle of lean and obese Zucker rats, basal, insulin-induced, and contraction-induced fatty acid transporter translocation and fatty acid uptake, esterification, and oxidation. In lean rats, insulin and contraction induced the translocation of the fatty acid transporter FAT/CD36 (43 and 41%, respectively) and plasma membrane-associated fatty acid binding protein (FABPpm; 19 and 60%) and increased fatty acid uptake (63 and 40%, respectively). Insulin and contraction increased lean muscle palmitate esterification and oxidation 72 and 61%, respectively. In obese rat muscle, basal levels of sarcolemmal FAT/CD36 (+33%) and FABPpm (+14%) and fatty acid uptake (+30%) and esterification (+32%) were increased, whereas fatty acid oxidation was reduced (−28%). Insulin stimulation of obese rat muscle increased plasmalemmal FABPpm (+15%) but not plasmalemmal FAT/CD36, blunted fatty acid uptake and esterification, and failed to reduce fatty acid oxidation. In contracting obese rat muscle, the increases in fatty acid uptake and esterification and FABPpm translocation were normal, but FAT/CD36 translocation was impaired and fatty acid oxidation was blunted. There was no relationship between plasmalemmal fatty acid transporters and palmitate partitioning. In conclusion, fatty acid metabolism is impaired at several levels in muscles of obese Zucker rats; specifically, they are 1) insulin resistant with respect to FAT/CD36 translocation and fatty acid uptake, esterification, and oxidation and 2) contraction resistant with respect to fatty acid oxidation and FAT/CD36 translocation, but, conversely, 3) obese muscles are neither insulin nor contraction resistant at the level of FABPpm. Finally, 4) there is no evidence that plasmalemmal fatty acid transporters contribute to the channeling of fatty acids to specific metabolic destinations within the muscle.

Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats

2004 ◽  
Vol 32 (1) ◽  
pp. 83-85 ◽  
Author(s):  
S.L.M. Coort ◽  
J.J.F.P. Luiken ◽  
G.J. van der Vusse ◽  
A. Bonen ◽  
J.F.C. Glatz
Keyword(s):  
Fatty Acid ◽  
Glucose Uptake ◽  
Cardiac Myocytes ◽  
Fatty Acid Uptake ◽  
Chain Fatty Acid ◽  
Zucker Rats ◽  
Acid Uptake ◽  
Long Chain Fatty Acid ◽  
Obese Zucker Rats ◽  
Long Chain

Disturbed cardiac lipid homoeostasis in obesity is regarded as a key player in the development of cardiovascular diseases. In this study, we show that FAT (fatty acid translocase)/CD36-mediated LCFA (long-chain fatty acid) uptake in cardiac myocytes from young adult obese Zucker rats is markedly increased, but insensitive to insulin. Basal and insulin-induced glucose uptake rates in these myocytes are not changed, suggesting that during the development from obesity to hyperglycaemic Type II diabetes, alterations in cardiac LCFA uptake precede alterations in cardiac glucose uptake.

scholarly journals Divergent effects of rosiglitazone on protein-mediated fatty acid uptake in adipose and in muscle tissues of Zucker rats

2005 ◽  
Vol 46 (6) ◽  
pp. 1295-1302 ◽  
Author(s):  
S. L. M. Coort ◽  
W. A. Coumans ◽  
A. Bonen ◽  
G. J. van der Vusse ◽  
J. F. C. Glatz ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Uptake ◽  
Zucker Rats ◽  
Acid Uptake ◽  
Muscle Tissues

scholarly journals Effects of insulin in vitro on lipogenesis and fatty acid uptake in white adipose tissue of Zucker rats aged 10 days

1984 ◽  
Vol 218 (2) ◽  
pp. 653-655 ◽  
Author(s):  
I de Waziers ◽  
E Planche
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Metabolic Pathways ◽  
Fatty Acid Uptake ◽  
Zucker Rats ◽  
Acid Uptake ◽  
Insulin Stimulation ◽  
Tissue Weight ◽  
Adipose Tissue Weight

Adipose-tissue lipogenesis and fatty acid uptake in vitro were higher in obese than in lean Zucker rats aged 10 days. On average, insulin stimulated each of these two metabolic pathways to the same extent in both genotypes. However, in fa/fa pups, we observed that insulin stimulation decreased when adipose-tissue weight increased.

Unaltered Fatty Acid Uptake, Utilization, and Mitochondrial Respiration in Right Atrial Appendage of Type 2 Diabetic Human Heart

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 335-OR
Author(s):  
NANDINI RJ ◽  
SR RAJI ◽  
VIVEK V. PILLAI ◽  
JAYAKUMAR K. ◽  
SRINIVAS GOPALA
Keyword(s):  
Fatty Acid ◽  
Mitochondrial Respiration ◽  
Human Heart ◽  
Fatty Acid Uptake ◽  
Atrial Appendage ◽  
Right Atrial ◽  
Acid Uptake ◽  
Right Atrial Appendage ◽  
Type 2 Diabetic
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