scholarly journals Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase-dependent Human Melanoma Invasion into Type I Collagen

2001 ◽  
Vol 276 (22) ◽  
pp. 18786-18794 ◽  
Author(s):  
Joji Iida ◽  
Duanqing Pei ◽  
Tiebang Kang ◽  
Melanie A. Simpson ◽  
Meenhard Herlyn ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Chondroitin Sulfate ◽  
Type I Collagen ◽  
Human Melanoma ◽  
Chondroitin Sulfate Proteoglycan ◽  
Type I ◽  
Sulfate Proteoglycan ◽  
Melanoma Invasion

scholarly journals Augmented Chondroitin Sulfate Proteoglycan Has Therapeutic Potential for Intervertebral Disc Degeneration by Stimulating Anabolic Turnover in Bovine Nucleus Pulposus Cells under Changes in Hydrostatic Pressure

2021 ◽  
Vol 22 (11) ◽  
pp. 6015
Author(s):  
Yoshiki Takeoka ◽  
Phani Paladugu ◽  
James D. Kang ◽  
Shuichi Mizuno
Keyword(s):  
Hydrostatic Pressure ◽  
Intervertebral Disc ◽  
Chondroitin Sulfate ◽  
Nucleus Pulposus ◽  
Transient Receptor Potential ◽  
Therapeutic Potential ◽  
Chondroitin Sulfate Proteoglycan ◽  
Transient Receptor Potential Vanilloid ◽  
Type I ◽  
Sulfate Proteoglycan

Nucleus pulposus (NP) cells are exposed to changes in hydrostatic pressure (HP) and osmotic pressure within the intervertebral disc. We focused on main disc matrix components, chondroitin sulfate proteoglycan (CSPG) and hyaluronan (HA) to elucidate the capability of augmented CSPG to enhance the anabolism of bovine NP (bNP) cells under repetitive changes in HP at high osmolality. Aggrecan expression with CSPG in the absence of HP was significantly upregulated compared to the no-material control (phosphate buffer saline) under no HP at 3 days, and aggrecan expression with CSPG under HP was significantly higher than the control with HA under HP at 12 days. Collagen type I expression under no HP was significantly lower with CSPG than in controls at 3 days. Although matrix metalloproteinase 13 expression under HP was downregulated compared to no HP, it was significantly greater with HA than the control and CSPG, even under HP. Immunohistology revealed the involvement of mechanoreceptor of transient receptor potential vanilloid-4 activation under HP, suggesting an HP transduction mechanism. Addition of CSPG had anabolic and anti-fibrotic effects on bNP cells during the early culture period under no HP; furthermore, it showed synergy with dynamic HP to increase bNP-cell anabolism at later time points.

scholarly journals Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan.

1996 ◽  
Vol 93 (18) ◽  
pp. 9710-9715 ◽  
Author(s):  
G. Pluschke ◽  
M. Vanek ◽  
A. Evans ◽  
T. Dittmar ◽  
P. Schmid ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Molecular Cloning ◽  
Human Melanoma ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

scholarly journals Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan

1998 ◽  
Vol 18 (14) ◽  
pp. 5203-5211 ◽  
Author(s):  
Jian Zuo ◽  
Toby A. Ferguson ◽  
Yosbani J. Hernandez ◽  
William G. Stetler-Stevenson ◽  
David Muir
Keyword(s):  
Matrix Metalloproteinase ◽  
Chondroitin Sulfate ◽  
Chondroitin Sulfate Proteoglycan ◽  
Matrix Metalloproteinase 2 ◽  
Sulfate Proteoglycan

Human melanoma/NG2 chondroitin sulfate proteoglycan is expressed in the sarcolemma of postnatal human skeletal myofibers

2003 ◽  
Vol 23 (2) ◽  
pp. 219-231 ◽  
Author(s):  
Stefania Petrini ◽  
Alessandra Tessa ◽  
Rosalba Carrozzo ◽  
Margherita Verardo ◽  
Roberta Pierini ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Human Melanoma ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan
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