Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel

M. Gabriele Bixel; Christoph Weise; Maria L. Bolognesi; Michela Rosini; Matthew J. Brierly; Ian R. Mellor; Peter N. R. Usherwood; Carlo Melchiorre; Ferdinand Hucho

doi:10.1074/jbc.m008467200

Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel

Journal of Biological Chemistry ◽

10.1074/jbc.m008467200 ◽

2000 ◽

Vol 276 (9) ◽

pp. 6151-6160 ◽

Cited By ~ 22

Author(s):

M. Gabriele Bixel ◽

Christoph Weise ◽

Maria L. Bolognesi ◽

Michela Rosini ◽

Matthew J. Brierly ◽

...

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Polyamine Binding Site

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Identification of Amino Acids in the Nicotinic Acetylcholine Receptor Agonist Binding Site and Ion Channel Photolabeled by 4-[(3-Trifluoromethyl)-3H-Diazirin-3-yl]Benzoylcholine, a Novel Photoaffinity Antagonist†

Biochemistry ◽

10.1021/bi0269815 ◽

2003 ◽

Vol 42 (2) ◽

pp. 271-283 ◽

Cited By ~ 14

Author(s):

David C. Chiara ◽

Jonathan C. Trinidad ◽

Dong Wang ◽

Michael R. Ziebell ◽

Deirdre Sullivan ◽

...

Keyword(s):

Amino Acids ◽

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Binding ◽

Nicotinic Acetylcholine

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Photolabeling reveals the proximity of the alpha-neurotoxin binding site to the M2 helix of the ion channel in the nicotinic acetylcholine receptor.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.92.16.7282 ◽

1995 ◽

Vol 92 (16) ◽

pp. 7282-7286 ◽

Cited By ~ 41

Author(s):

J. Machold ◽

Y. Utkin ◽

D. Kirsch ◽

R. Kaufmann ◽

V. Tsetlin ◽

...

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Examining the Noncompetitive Antagonist-binding Site in the Ion Channel of the Nicotinic Acetylcholine Receptor in the Resting State

Journal of Biological Chemistry ◽

10.1074/jbc.275.5.3469 ◽

2000 ◽

Vol 275 (5) ◽

pp. 3469-3478 ◽

Cited By ~ 14

Author(s):

Michael P. Blanton ◽

Elizabeth A. McCardy ◽

Martin J. Gallagher

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Resting State ◽

Nicotinic Acetylcholine ◽

Antagonist Binding

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The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor

Chemistry & Biology ◽

10.1016/s1074-5521(00)00055-7 ◽

2001 ◽

Vol 8 (1) ◽

pp. 47-58 ◽

Cited By ~ 22

Author(s):

Lintong Li ◽

Wenge Zhong ◽

Niki Zacharias ◽

Caroline Gibbs ◽

Henry A Lester ◽

...

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structural Model ◽

Agonist Binding ◽

Nicotinic Acetylcholine ◽

Channel Proteins ◽

Ion Channel Proteins

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Architecture of the Neuronal Nicotinic Acetylcholine Receptor Ion Channel at the Binding Site of bis-Ammonium Blockers

The Journal of Membrane Biology ◽

10.1007/s002329900087 ◽

1996 ◽

Vol 152 (1) ◽

pp. 77-87 ◽

Cited By ~ 9

Author(s):

N.B. Brovtsyna ◽

D.B. Tikhonov ◽

O.B. Gorbunova ◽

V.E. Gmiro ◽

S.E. Serduk ◽

...

Keyword(s):

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54504-x ◽

1991 ◽

Vol 266 (34) ◽

pp. 23354-23364

Author(s):

J.B. Cohen ◽

S.D. Sharp ◽

W.S. Liu

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cation Binding ◽

Agonist Binding ◽

Nicotinic Acetylcholine

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Expression of the alpha-bungarotoxin binding site of the nicotinic acetylcholine receptor by Escherichia coli transformants.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.84.12.4318 ◽

1987 ◽

Vol 84 (12) ◽

pp. 4318-4321 ◽

Cited By ~ 44

Author(s):

J. M. Gershoni

Keyword(s):

Escherichia Coli ◽

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha Bungarotoxin

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Probing the Agonist Domain of the Nicotinic Acetylcholine Receptor by Cysteine Scanning Mutagenesis Reveals Residues in Proximity to the α-Bungarotoxin Binding Site†

Biochemistry ◽

10.1021/bi982656z ◽

1999 ◽

Vol 38 (16) ◽

pp. 4912-4921 ◽

Cited By ~ 18

Author(s):

Armin Spura ◽

Tanya S. Russin ◽

Neal D. Freedman ◽

Marianne Grant ◽

James T. McLaughlin ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cysteine Scanning ◽

Cysteine Scanning Mutagenesis

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An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Journal of Biological Chemistry ◽

10.1074/jbc.m117.815316 ◽

2017 ◽

Vol 293 (7) ◽

pp. 2534-2545 ◽

Cited By ~ 15

Author(s):

Florian Delbart ◽

Marijke Brams ◽

Fabian Gruss ◽

Sam Noppen ◽

Steve Peigneur ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein

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A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.708 ◽

2010 ◽

Vol 98 (3) ◽

pp. 131a

Author(s):

Ayman K. Hamouda ◽

Deidre Stewart ◽

S. Shaukat Husain ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface ◽

A Subunit

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